Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016.
A care cascade is a critical tool for evaluating delivery of care for chronic infections across sequential stages, starting with diagnosis and ending with viral suppression. However, there have been few data describing the hepatitis B virus (HBV) care cascade among people living with HIV infection w...
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Public Library of Science (PLoS)
2023-01-01
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| author | Jessica Kim Craig W Newcomb Dean Carbonari Jessie Torgersen Keri N Althoff Mari M Kitahata Marina B Klein Richard D Moore K Rajender Reddy Michael J Silverberg Angel M Mayor Michael A Horberg Edward R Cachay Joseph K Lim M John Gill Kara Chew Timothy R Sterling Mark Hull Eric C Seaberg Gregory D Kirk Sally B Coburn Raynell Lang Kathleen A McGinnis Kelly A Gebo Sonia Napravnik H Nina Kim Vincent Lo Re North American AIDS Cohort Collaboration on Research and Design of IeDEA |
| author_facet | Jessica Kim Craig W Newcomb Dean Carbonari Jessie Torgersen Keri N Althoff Mari M Kitahata Marina B Klein Richard D Moore K Rajender Reddy Michael J Silverberg Angel M Mayor Michael A Horberg Edward R Cachay Joseph K Lim M John Gill Kara Chew Timothy R Sterling Mark Hull Eric C Seaberg Gregory D Kirk Sally B Coburn Raynell Lang Kathleen A McGinnis Kelly A Gebo Sonia Napravnik H Nina Kim Vincent Lo Re North American AIDS Cohort Collaboration on Research and Design of IeDEA |
| author_sort | Jessica Kim |
| collection | DOAJ |
| description | A care cascade is a critical tool for evaluating delivery of care for chronic infections across sequential stages, starting with diagnosis and ending with viral suppression. However, there have been few data describing the hepatitis B virus (HBV) care cascade among people living with HIV infection who have HBV coinfection. We conducted a cross-sectional study among people living with HIV and HBV coinfection receiving care between January 1, 2012 and December 31, 2016 within 13 United States and Canadian clinical cohorts contributing data to the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). We evaluated each of the steps in this cascade, including: 1) laboratory-confirmed HBV infection, 2) tenofovir-based or entecavir-based HBV therapy prescribed, 3) HBV DNA measured during treatment, and 4) viral suppression achieved via undetectable HBV DNA. Among 3,953 persons with laboratory-confirmed HBV (median age, 50 years; 6.5% female; 43.8% were Black; 7.1% were Hispanic), 3,592 (90.9%; 95% confidence interval, 90.0-91.8%) were prescribed tenofovir-based antiretroviral therapy or entecavir along with their antiretroviral therapy regimen, 2,281 (57.7%; 95% confidence interval, 56.2-59.2%) had HBV DNA measured while on therapy, and 1,624 (41.1%; 95% confidence interval, 39.5-42.6) achieved an undetectable HBV DNA during HBV treatment. Our study identified significant gaps in measurement of HBV DNA and suppression of HBV viremia among people living with HIV and HBV coinfection in the United States and Canada. Periodic evaluation of the HBV care cascade among persons with HIV/HBV will be critical to monitoring success in completion of each step. |
| format | Article |
| id | doaj-art-db25ba33c76849cfacd069af9da644ef |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
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| spelling | doaj-art-db25ba33c76849cfacd069af9da644ef2025-01-18T05:31:02ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01189e029088910.1371/journal.pone.0290889Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016.Jessica KimCraig W NewcombDean CarbonariJessie TorgersenKeri N AlthoffMari M KitahataMarina B KleinRichard D MooreK Rajender ReddyMichael J SilverbergAngel M MayorMichael A HorbergEdward R CachayJoseph K LimM John GillKara ChewTimothy R SterlingMark HullEric C SeabergGregory D KirkSally B CoburnRaynell LangKathleen A McGinnisKelly A GeboSonia NapravnikH Nina KimVincent Lo ReNorth American AIDS Cohort Collaboration on Research and Design of IeDEAA care cascade is a critical tool for evaluating delivery of care for chronic infections across sequential stages, starting with diagnosis and ending with viral suppression. However, there have been few data describing the hepatitis B virus (HBV) care cascade among people living with HIV infection who have HBV coinfection. We conducted a cross-sectional study among people living with HIV and HBV coinfection receiving care between January 1, 2012 and December 31, 2016 within 13 United States and Canadian clinical cohorts contributing data to the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). We evaluated each of the steps in this cascade, including: 1) laboratory-confirmed HBV infection, 2) tenofovir-based or entecavir-based HBV therapy prescribed, 3) HBV DNA measured during treatment, and 4) viral suppression achieved via undetectable HBV DNA. Among 3,953 persons with laboratory-confirmed HBV (median age, 50 years; 6.5% female; 43.8% were Black; 7.1% were Hispanic), 3,592 (90.9%; 95% confidence interval, 90.0-91.8%) were prescribed tenofovir-based antiretroviral therapy or entecavir along with their antiretroviral therapy regimen, 2,281 (57.7%; 95% confidence interval, 56.2-59.2%) had HBV DNA measured while on therapy, and 1,624 (41.1%; 95% confidence interval, 39.5-42.6) achieved an undetectable HBV DNA during HBV treatment. Our study identified significant gaps in measurement of HBV DNA and suppression of HBV viremia among people living with HIV and HBV coinfection in the United States and Canada. Periodic evaluation of the HBV care cascade among persons with HIV/HBV will be critical to monitoring success in completion of each step.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290889&type=printable |
| spellingShingle | Jessica Kim Craig W Newcomb Dean Carbonari Jessie Torgersen Keri N Althoff Mari M Kitahata Marina B Klein Richard D Moore K Rajender Reddy Michael J Silverberg Angel M Mayor Michael A Horberg Edward R Cachay Joseph K Lim M John Gill Kara Chew Timothy R Sterling Mark Hull Eric C Seaberg Gregory D Kirk Sally B Coburn Raynell Lang Kathleen A McGinnis Kelly A Gebo Sonia Napravnik H Nina Kim Vincent Lo Re North American AIDS Cohort Collaboration on Research and Design of IeDEA Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. PLoS ONE |
| title | Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. |
| title_full | Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. |
| title_fullStr | Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. |
| title_full_unstemmed | Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. |
| title_short | Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. |
| title_sort | hepatitis b care cascade among people with hiv hbv coinfection in the north american aids cohort collaboration on research and design 2012 2016 |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0290889&type=printable |
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