The Role of Butirprost<sup>®</sup> as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial
Bacterial prostatitis (BP) is a common prostatic infection characterized by pain and urinary symptoms, often with negative bacterial cultures from prostatic secretions. It affects young and older men bimodally and impacts quality of life (QoL) significantly. <i>Background and Objectives</i&...
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2025-01-01
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| author | Felice Crocetto Armando Calogero Michele Santangelo Agostino Fernicola Filippo Varlese Benito Fabio Mirto Fabio Machiella Alfonso Falcone Giovanni Pagano Fabrizio Dinacci Gaetano Giampaglia Domenico Varriale Francesco Trama Salvatore Iaconis Francesco Del Giudice Gian Maria Busetto Matteo Ferro Francesco Lasorsa Giuseppe Lucarelli Ciro Imbimbo Biagio Barone |
| author_facet | Felice Crocetto Armando Calogero Michele Santangelo Agostino Fernicola Filippo Varlese Benito Fabio Mirto Fabio Machiella Alfonso Falcone Giovanni Pagano Fabrizio Dinacci Gaetano Giampaglia Domenico Varriale Francesco Trama Salvatore Iaconis Francesco Del Giudice Gian Maria Busetto Matteo Ferro Francesco Lasorsa Giuseppe Lucarelli Ciro Imbimbo Biagio Barone |
| author_sort | Felice Crocetto |
| collection | DOAJ |
| description | Bacterial prostatitis (BP) is a common prostatic infection characterized by pain and urinary symptoms, often with negative bacterial cultures from prostatic secretions. It affects young and older men bimodally and impacts quality of life (QoL) significantly. <i>Background and Objectives</i>: Treatment typically involves antibiotics, but a multimodal approach with additional nutraceuticals may enhance outcomes. This study aimed to assess the efficacy of Butirprost<sup>®</sup> in association with fluoroquinolones in patients with chronic bacterial prostatitis (CBP). <i>Materials and Methods</i>: Patients diagnosed with prostatitis (positive Meares–Stamey test and symptom duration > 3 months) at the University of Naples “Federico II”, Italy, from March 2024 to July 2024 were included in this study. All patients underwent bacterial cultures. Patients were randomized into two groups: Group A received antibiotics plus Butirprost<sup>®</sup> (sodium hyaluronate plus Plantago major) for one month, while Group B received antibiotics alone. International Prostatic Symptoms Score (IPSS) and National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) questionnaires were administered at baseline and at 15 and 30 days. <i>Results</i>: Out of 60 patients (Group A: 30, Group B: 30), Group A showed significant improvement in IPSS and NIH-CPSI scores at 15 and 30 days compared to Group B. Notable improvements were observed in pain, urinary symptoms, and QoL. <i>Conclusions</i>: The administration of Butirprost<sup>®</sup> along with fluoroquinolones resulted in a significant improvement in pain, urinary symptoms, and quality of life along with improvements in both IPSS and NIH-CPSI scores, in patients affected by chronic bacterial prostatitis compared with fluoroquinolones alone. |
| format | Article |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-db18f40746b643ddbc9f3f03d96e51e72025-01-24T13:40:51ZengMDPI AGMedicina1010-660X1648-91442025-01-0161114810.3390/medicina61010148The Role of Butirprost<sup>®</sup> as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective TrialFelice Crocetto0Armando Calogero1Michele Santangelo2Agostino Fernicola3Filippo Varlese4Benito Fabio Mirto5Fabio Machiella6Alfonso Falcone7Giovanni Pagano8Fabrizio Dinacci9Gaetano Giampaglia10Domenico Varriale11Francesco Trama12Salvatore Iaconis13Francesco Del Giudice14Gian Maria Busetto15Matteo Ferro16Francesco Lasorsa17Giuseppe Lucarelli18Ciro Imbimbo19Biagio Barone20Department of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalySection of General Surgery, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, ItalySection of General Surgery, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, ItalySection of General Surgery, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, ItalySection of General Surgery, Department of Advanced Biomedical Sciences, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyUrology Complex Unit, ASL Napoli 2 Nord ‘Santa Maria delle Grazie’ Hospital, 80078 Pozzuoli, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Urology, Policlinico Umberto I, Sapienza University of Rome, 00185 Rome, ItalyDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, ItalyDivision of Urology, European Institute of Oncology (IEO) IRCCS, 20139 Milan, ItalyDepartment of Urology and Organ Transplantation, University of Foggia, 71122 Foggia, ItalyUrology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area-Urology, University of Bari “Aldo Moro”, 70121 Bari, ItalyDepartment of Neurosciences, Sciences of Reproduction and Odontostomatology, University of Naples Federico II, 80131 Naples, ItalyDepartment of Urology, 196152 Ospedale San Paolo, ASL NA1 Centro Naples, 80145 Naples, ItalyBacterial prostatitis (BP) is a common prostatic infection characterized by pain and urinary symptoms, often with negative bacterial cultures from prostatic secretions. It affects young and older men bimodally and impacts quality of life (QoL) significantly. <i>Background and Objectives</i>: Treatment typically involves antibiotics, but a multimodal approach with additional nutraceuticals may enhance outcomes. This study aimed to assess the efficacy of Butirprost<sup>®</sup> in association with fluoroquinolones in patients with chronic bacterial prostatitis (CBP). <i>Materials and Methods</i>: Patients diagnosed with prostatitis (positive Meares–Stamey test and symptom duration > 3 months) at the University of Naples “Federico II”, Italy, from March 2024 to July 2024 were included in this study. All patients underwent bacterial cultures. Patients were randomized into two groups: Group A received antibiotics plus Butirprost<sup>®</sup> (sodium hyaluronate plus Plantago major) for one month, while Group B received antibiotics alone. International Prostatic Symptoms Score (IPSS) and National Institutes of Health Chronic Prostatitis Symptom Index (NIH-CPSI) questionnaires were administered at baseline and at 15 and 30 days. <i>Results</i>: Out of 60 patients (Group A: 30, Group B: 30), Group A showed significant improvement in IPSS and NIH-CPSI scores at 15 and 30 days compared to Group B. Notable improvements were observed in pain, urinary symptoms, and QoL. <i>Conclusions</i>: The administration of Butirprost<sup>®</sup> along with fluoroquinolones resulted in a significant improvement in pain, urinary symptoms, and quality of life along with improvements in both IPSS and NIH-CPSI scores, in patients affected by chronic bacterial prostatitis compared with fluoroquinolones alone.https://www.mdpi.com/1648-9144/61/1/148bacterial prostatitisantibioticsLUTSQoLIPSShyaluronic acid |
| spellingShingle | Felice Crocetto Armando Calogero Michele Santangelo Agostino Fernicola Filippo Varlese Benito Fabio Mirto Fabio Machiella Alfonso Falcone Giovanni Pagano Fabrizio Dinacci Gaetano Giampaglia Domenico Varriale Francesco Trama Salvatore Iaconis Francesco Del Giudice Gian Maria Busetto Matteo Ferro Francesco Lasorsa Giuseppe Lucarelli Ciro Imbimbo Biagio Barone The Role of Butirprost<sup>®</sup> as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial Medicina bacterial prostatitis antibiotics LUTS QoL IPSS hyaluronic acid |
| title | The Role of Butirprost<sup>®</sup> as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial |
| title_full | The Role of Butirprost<sup>®</sup> as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial |
| title_fullStr | The Role of Butirprost<sup>®</sup> as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial |
| title_full_unstemmed | The Role of Butirprost<sup>®</sup> as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial |
| title_short | The Role of Butirprost<sup>®</sup> as an Adjuvant in Enhancing the Effect of Antibiotics in Patients Affected by Chronic Bacterial Prostatitis: A Randomized Prospective Trial |
| title_sort | role of butirprost sup r sup as an adjuvant in enhancing the effect of antibiotics in patients affected by chronic bacterial prostatitis a randomized prospective trial |
| topic | bacterial prostatitis antibiotics LUTS QoL IPSS hyaluronic acid |
| url | https://www.mdpi.com/1648-9144/61/1/148 |
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