Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation

Steroids and Malignancy Increase Local Heparanase and Decrease Markers of Osteoblast Activity in Bone Tissue Microcirculation

Bone metastasis and steroids are known to activate the coagulation system and induce osteoporosis, pathological bone fractures, and bone pain. Heparanase is a protein known to enhance the hemostatic system and to promote angiogenesis, metastasis, and inflammation. The objective of the present study...

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Bibliographic Details
Main Authors: Keren Asayag, Eli Peled, Mai Assalia, Yonatan Crispel, Chen Yanovich, Haim Cohen, Anat Keren-Politansky, Yona Nadir
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Biomolecules
Subjects:
bone
microcirculation
thrombosis
heparanase
steroids
malignancy
Online Access:https://www.mdpi.com/2218-273X/14/12/1506
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