Pathogenesis of anemia in pregnant women with gestational diabetes mellitus
The aim of the research was to establish the role of inflammation mediators and iron metabolism in the pathogenesis of various types of anemic syndrome in pregnant women with gestational diabetes mellitus (GDM).Materials and methods. 32 pregnant patients with GDM were examined; 14 of them had iron d...
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Siberian State Medical University (Tomsk)
2020-07-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/2855 |
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| author | A. P. Zima T. S. Prokhorenko T. V. Saprina N. N. Musina V. V. Novitsky A. N. Baykov |
| author_facet | A. P. Zima T. S. Prokhorenko T. V. Saprina N. N. Musina V. V. Novitsky A. N. Baykov |
| author_sort | A. P. Zima |
| collection | DOAJ |
| description | The aim of the research was to establish the role of inflammation mediators and iron metabolism in the pathogenesis of various types of anemic syndrome in pregnant women with gestational diabetes mellitus (GDM).Materials and methods. 32 pregnant patients with GDM were examined; 14 of them had iron deficiency anemia, 18 – anemia of chronic diseases. The enzyme-linked immunosorbent assay was used to determine the concentration of IL-6, hepcidin and a soluble receptor for transferrin in the blood serum of pregnant women, the concentrations of C-reactive protein and transferrin were determined with the method of turbidimetry.Results. It was shown that women with GDM had higher IL-6 level compared to healthy pregnant women, and the concentration of IL-6 did not depend on the type of anemic syndrome. The C-reactive protein concentration was higher in patients with GDM and anemia of chronic diseases than in healthy pregnant women or in pregnant women with iron deficiency anemia. An analysis of iron metabolism markers in pregnant women with GDM established that patients with anemia of chronic diseases had higher hepcidin levels than women with iron deficiency anemia or healthy pregnant women.Conclusions. We established the heterogeneity of the anemic syndrome in pregnancy complicated by GDM. It was confirmed that GDM was accompanied by subclinical inflammation, which was more pronounced in anemia of chronic diseases. The research showed that the mechanism of development of anemia of chronic diseases involving the hepcidin protein was also realized in GDM, characterized by subclinical inflammation. The results indicate the importance of establishing the type of the anemic syndrome in pregnant women with GDM for effective therapeutic follow-up. |
| format | Article |
| id | doaj-art-db166b0530c744b4831333fe11761936 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2020-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-db166b0530c744b4831333fe117619362025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842020-07-01192283310.20538/1682-0363-2020-2-28-331617Pathogenesis of anemia in pregnant women with gestational diabetes mellitusA. P. Zima0T. S. Prokhorenko1T. V. Saprina2N. N. Musina3V. V. Novitsky4A. N. Baykov5Siberian State Medical UniversitySiberian State Medical University; Tomsk Regional Blood CenterSiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversitySiberian State Medical UniversityThe aim of the research was to establish the role of inflammation mediators and iron metabolism in the pathogenesis of various types of anemic syndrome in pregnant women with gestational diabetes mellitus (GDM).Materials and methods. 32 pregnant patients with GDM were examined; 14 of them had iron deficiency anemia, 18 – anemia of chronic diseases. The enzyme-linked immunosorbent assay was used to determine the concentration of IL-6, hepcidin and a soluble receptor for transferrin in the blood serum of pregnant women, the concentrations of C-reactive protein and transferrin were determined with the method of turbidimetry.Results. It was shown that women with GDM had higher IL-6 level compared to healthy pregnant women, and the concentration of IL-6 did not depend on the type of anemic syndrome. The C-reactive protein concentration was higher in patients with GDM and anemia of chronic diseases than in healthy pregnant women or in pregnant women with iron deficiency anemia. An analysis of iron metabolism markers in pregnant women with GDM established that patients with anemia of chronic diseases had higher hepcidin levels than women with iron deficiency anemia or healthy pregnant women.Conclusions. We established the heterogeneity of the anemic syndrome in pregnancy complicated by GDM. It was confirmed that GDM was accompanied by subclinical inflammation, which was more pronounced in anemia of chronic diseases. The research showed that the mechanism of development of anemia of chronic diseases involving the hepcidin protein was also realized in GDM, characterized by subclinical inflammation. The results indicate the importance of establishing the type of the anemic syndrome in pregnant women with GDM for effective therapeutic follow-up.https://bulletin.ssmu.ru/jour/article/view/2855pregnancyanemia of chronic diseasesgestational diabetes mellitusinflammationhepcidin |
| spellingShingle | A. P. Zima T. S. Prokhorenko T. V. Saprina N. N. Musina V. V. Novitsky A. N. Baykov Pathogenesis of anemia in pregnant women with gestational diabetes mellitus Бюллетень сибирской медицины pregnancy anemia of chronic diseases gestational diabetes mellitus inflammation hepcidin |
| title | Pathogenesis of anemia in pregnant women with gestational diabetes mellitus |
| title_full | Pathogenesis of anemia in pregnant women with gestational diabetes mellitus |
| title_fullStr | Pathogenesis of anemia in pregnant women with gestational diabetes mellitus |
| title_full_unstemmed | Pathogenesis of anemia in pregnant women with gestational diabetes mellitus |
| title_short | Pathogenesis of anemia in pregnant women with gestational diabetes mellitus |
| title_sort | pathogenesis of anemia in pregnant women with gestational diabetes mellitus |
| topic | pregnancy anemia of chronic diseases gestational diabetes mellitus inflammation hepcidin |
| url | https://bulletin.ssmu.ru/jour/article/view/2855 |
| work_keys_str_mv | AT apzima pathogenesisofanemiainpregnantwomenwithgestationaldiabetesmellitus AT tsprokhorenko pathogenesisofanemiainpregnantwomenwithgestationaldiabetesmellitus AT tvsaprina pathogenesisofanemiainpregnantwomenwithgestationaldiabetesmellitus AT nnmusina pathogenesisofanemiainpregnantwomenwithgestationaldiabetesmellitus AT vvnovitsky pathogenesisofanemiainpregnantwomenwithgestationaldiabetesmellitus AT anbaykov pathogenesisofanemiainpregnantwomenwithgestationaldiabetesmellitus |