Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds
Abstract In the first part of this study, magnetic nanoparticles were decorated with folic acid (Vitamin B9) under ultrasonic agitation in water, resulting in heterogeneous nano-biocatalysts (FA@γ-Fe2O3), which were characterized using different techniques, such as VSM, FT-IR, and FESEM. The efficie...
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Nature Portfolio
2025-08-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-15308-x |
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| author | Maasoumeh Jafarpour Abdolreza Rezaeifard Narges Pourmorteza Rashid Ghermezi Fatemeh Salkhordeh |
| author_facet | Maasoumeh Jafarpour Abdolreza Rezaeifard Narges Pourmorteza Rashid Ghermezi Fatemeh Salkhordeh |
| author_sort | Maasoumeh Jafarpour |
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| description | Abstract In the first part of this study, magnetic nanoparticles were decorated with folic acid (Vitamin B9) under ultrasonic agitation in water, resulting in heterogeneous nano-biocatalysts (FA@γ-Fe2O3), which were characterized using different techniques, such as VSM, FT-IR, and FESEM. The efficiency of the as-prepared magnetic nanocatalyst was assessed in the synthesis of quinoxaline derivatives. In the second part, a Cu (II) folic acid complex was used for modifying the surface of γ-Fe2O3 (FA-Cu@γ-Fe2O3). It was used successfully in several different transformations in a one-pot reaction sequence, including the aerobic oxidation of benzylic alcohols to aldehydes and the tandem synthesis of benzimidazoles through the dehydrogenative coupling of primary benzylic alcohols and aromatic diamines. The biocatalysts maintained their efficiency and structural integrity after 4 runs, which confirmed that components are firmly bonded. The advantages of these catalytic systems include easy separation and reusability of the solid catalyst for subsequent rounds of reactions with an external magnet, demonstrating great potential for practical applications. |
| format | Article |
| id | doaj-art-db11a96473fb45469fe91bbcc091f6cf |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-db11a96473fb45469fe91bbcc091f6cf2025-08-24T11:18:56ZengNature PortfolioScientific Reports2045-23222025-08-0115111310.1038/s41598-025-15308-xMagnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compoundsMaasoumeh Jafarpour0Abdolreza Rezaeifard1Narges Pourmorteza2Rashid Ghermezi3Fatemeh Salkhordeh4Department of Organic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityDepartment of Inorganic Chemistry, Faculty of Chemistry and Petroleum Sciences, Bu-Ali Sina UniversityCatalysis Research Laboratory, Department of Chemistry, Faculty of Science, University of BirjandCatalysis Research Laboratory, Department of Chemistry, Faculty of Science, University of BirjandCatalysis Research Laboratory, Department of Chemistry, Faculty of Science, University of BirjandAbstract In the first part of this study, magnetic nanoparticles were decorated with folic acid (Vitamin B9) under ultrasonic agitation in water, resulting in heterogeneous nano-biocatalysts (FA@γ-Fe2O3), which were characterized using different techniques, such as VSM, FT-IR, and FESEM. The efficiency of the as-prepared magnetic nanocatalyst was assessed in the synthesis of quinoxaline derivatives. In the second part, a Cu (II) folic acid complex was used for modifying the surface of γ-Fe2O3 (FA-Cu@γ-Fe2O3). It was used successfully in several different transformations in a one-pot reaction sequence, including the aerobic oxidation of benzylic alcohols to aldehydes and the tandem synthesis of benzimidazoles through the dehydrogenative coupling of primary benzylic alcohols and aromatic diamines. The biocatalysts maintained their efficiency and structural integrity after 4 runs, which confirmed that components are firmly bonded. The advantages of these catalytic systems include easy separation and reusability of the solid catalyst for subsequent rounds of reactions with an external magnet, demonstrating great potential for practical applications.https://doi.org/10.1038/s41598-025-15308-xVitamin B9Folic acidAerobic oxidationMagnetic nanoparticlesN-heterocyclic compounds |
| spellingShingle | Maasoumeh Jafarpour Abdolreza Rezaeifard Narges Pourmorteza Rashid Ghermezi Fatemeh Salkhordeh Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds Scientific Reports Vitamin B9 Folic acid Aerobic oxidation Magnetic nanoparticles N-heterocyclic compounds |
| title | Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds |
| title_full | Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds |
| title_fullStr | Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds |
| title_full_unstemmed | Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds |
| title_short | Magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds |
| title_sort | magnetic nanohybrids of folic acid as green biocatalysts for the synthesis of heterocyclic compounds |
| topic | Vitamin B9 Folic acid Aerobic oxidation Magnetic nanoparticles N-heterocyclic compounds |
| url | https://doi.org/10.1038/s41598-025-15308-x |
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