Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. Petersburg
Aim. Estimation of the liver steatosis and fibrosis incidence with transient elastography and the controlled attenuation parameter in residents of St. Petersburg.Materials and methods. A prospective open single-centre population study included history, anthropometric and laboratory data on 318 outpa...
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| Format: | Article |
| Language: | Russian |
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Gastro LLC
2021-04-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/527 |
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| author | V. P. Kovyazina K. L. Raikhelson M. K. Prashnova E. V. Pazenko L. K. Palgova E. A. Kondrashina |
| author_facet | V. P. Kovyazina K. L. Raikhelson M. K. Prashnova E. V. Pazenko L. K. Palgova E. A. Kondrashina |
| author_sort | V. P. Kovyazina |
| collection | DOAJ |
| description | Aim. Estimation of the liver steatosis and fibrosis incidence with transient elastography and the controlled attenuation parameter in residents of St. Petersburg.Materials and methods. A prospective open single-centre population study included history, anthropometric and laboratory data on 318 outpatients aged 24—89 years (mean age 52.6 ± 14.6 years). The degrees of steatosis (assessed with the controlled attenuation parameter as ultrasound amplitude dropdown quantification in liver) and fibrosis were determined with a Fibroscan 502 Touch unit (Echosens, France).Results. Hepatic steatosis of predominantly high degree was revealed in 44.7%, combined fibrosis and steatosis — in 28%; isolated fibrosis of various stage — in 2.5%, no structural changes — in 24.8% individuals. The growth of body mass index and waist circumference significantly correlated in women with pronounced liver changes. Serum transaminase activity increased with more severe liver changes, being statistically significant for aspartic transaminase only.Conclusion. A high incidence of primary liver steatosis and fibrosis in residents of St. Petersburg warrants improved diagnostic algorithms and routine preventive measures. Transient elastography with the controlled attenuation parameter estimation provides a convenient non-invasive screening for hepatic fibrosis and steatosis. |
| format | Article |
| id | doaj-art-db0e6651d9e24d54ba59afd205ad066d |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2021-04-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-db0e6651d9e24d54ba59afd205ad066d2025-02-10T16:14:36ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732021-04-01311313810.22416/1382-4376-2021-31-1-31-38409Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. PetersburgV. P. Kovyazina0K. L. Raikhelson1M. K. Prashnova2E. V. Pazenko3L. K. Palgova4E. A. Kondrashina5Saint-Petersburg State UniversitySaint-Petersburg State UniversitySaint-Petersburg State UniversitySaint-Petersburg State UniversitySaint-Petersburg State UniversitySaint-Petersburg State UniversityAim. Estimation of the liver steatosis and fibrosis incidence with transient elastography and the controlled attenuation parameter in residents of St. Petersburg.Materials and methods. A prospective open single-centre population study included history, anthropometric and laboratory data on 318 outpatients aged 24—89 years (mean age 52.6 ± 14.6 years). The degrees of steatosis (assessed with the controlled attenuation parameter as ultrasound amplitude dropdown quantification in liver) and fibrosis were determined with a Fibroscan 502 Touch unit (Echosens, France).Results. Hepatic steatosis of predominantly high degree was revealed in 44.7%, combined fibrosis and steatosis — in 28%; isolated fibrosis of various stage — in 2.5%, no structural changes — in 24.8% individuals. The growth of body mass index and waist circumference significantly correlated in women with pronounced liver changes. Serum transaminase activity increased with more severe liver changes, being statistically significant for aspartic transaminase only.Conclusion. A high incidence of primary liver steatosis and fibrosis in residents of St. Petersburg warrants improved diagnostic algorithms and routine preventive measures. Transient elastography with the controlled attenuation parameter estimation provides a convenient non-invasive screening for hepatic fibrosis and steatosis.https://www.gastro-j.ru/jour/article/view/527non-alcoholic fatty liver diseasenon-alcoholic steatohepatitissteatosisfibrosistransient elastographycontrolled attenuation parameter |
| spellingShingle | V. P. Kovyazina K. L. Raikhelson M. K. Prashnova E. V. Pazenko L. K. Palgova E. A. Kondrashina Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. Petersburg Российский журнал гастроэнтерологии, гепатологии, колопроктологии non-alcoholic fatty liver disease non-alcoholic steatohepatitis steatosis fibrosis transient elastography controlled attenuation parameter |
| title | Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. Petersburg |
| title_full | Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. Petersburg |
| title_fullStr | Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. Petersburg |
| title_full_unstemmed | Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. Petersburg |
| title_short | Detectability of Liver Steatosis and Fibrosis with Transient Elastography and Controlled Attenuation Parameter in Residents of St. Petersburg |
| title_sort | detectability of liver steatosis and fibrosis with transient elastography and controlled attenuation parameter in residents of st petersburg |
| topic | non-alcoholic fatty liver disease non-alcoholic steatohepatitis steatosis fibrosis transient elastography controlled attenuation parameter |
| url | https://www.gastro-j.ru/jour/article/view/527 |
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