Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation
Head and neck cancer (HNC) remains a significant challenge in oncology due to poor drug delivery and an immunosuppressive tumour microenvironment (TME). This review focuses on the role of nanoparticles (NPs) in addressing challenges in HNC treatment, highlighting their potential to enhance efficienc...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2025-12-01
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| Series: | Nano TransMed |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2790676025000068 |
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| author | Karthikeyan Elumalai Sivaneswari Srinivasan |
| author_facet | Karthikeyan Elumalai Sivaneswari Srinivasan |
| author_sort | Karthikeyan Elumalai |
| collection | DOAJ |
| description | Head and neck cancer (HNC) remains a significant challenge in oncology due to poor drug delivery and an immunosuppressive tumour microenvironment (TME). This review focuses on the role of nanoparticles (NPs) in addressing challenges in HNC treatment, highlighting their potential to enhance efficiency and targeting. Researchers are studying different kinds of NPs, like liposomal, polymeric, dendritic, and gold nanoparticles (AuNPs), to see how they can improve drug delivery and change the tumour environment. To improve treatment results, we use specific strategies like targeting receptors, releasing substances inside cells in a controlled way, and adjusting the immune response. The review talks about how NPs focus on cancer-related fibroblasts, stop new blood vessel growth, and tackle problems in moving these treatments into real-world use. These issues include safety, toxicity, being able to produce them on a large scale, and following regulations. Finally, emerging trends, such as hybrid NPs and personalized nanomedicine, are proposed. Nanoparticle technology can greatly change how we treat head and neck cancer. It can improve how drugs are delivered, alter the environment around tumours, and tailor treatments to individual patients, which can make life better for them. This could lead to a new approach in cancer care.in cancer treatment. |
| format | Article |
| id | doaj-art-db09441f0c3e4fb3a672a08f9000f556 |
| institution | DOAJ |
| issn | 2790-6760 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Nano TransMed |
| spelling | doaj-art-db09441f0c3e4fb3a672a08f9000f5562025-08-20T03:04:42ZengKeAi Communications Co., Ltd.Nano TransMed2790-67602025-12-01410007510.1016/j.ntm.2025.100075Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translationKarthikeyan Elumalai0Sivaneswari Srinivasan1Deprtment of Pharmaceutical Chemistry Saveetha College of Pharmacy, Saveetha Institute of Medical and Technical Sciences, Chennai 602105, IndiaDepartment of Pharmaceutics, KK College of Pharmacy, Chennai 600116, India; Corresponding author.Head and neck cancer (HNC) remains a significant challenge in oncology due to poor drug delivery and an immunosuppressive tumour microenvironment (TME). This review focuses on the role of nanoparticles (NPs) in addressing challenges in HNC treatment, highlighting their potential to enhance efficiency and targeting. Researchers are studying different kinds of NPs, like liposomal, polymeric, dendritic, and gold nanoparticles (AuNPs), to see how they can improve drug delivery and change the tumour environment. To improve treatment results, we use specific strategies like targeting receptors, releasing substances inside cells in a controlled way, and adjusting the immune response. The review talks about how NPs focus on cancer-related fibroblasts, stop new blood vessel growth, and tackle problems in moving these treatments into real-world use. These issues include safety, toxicity, being able to produce them on a large scale, and following regulations. Finally, emerging trends, such as hybrid NPs and personalized nanomedicine, are proposed. Nanoparticle technology can greatly change how we treat head and neck cancer. It can improve how drugs are delivered, alter the environment around tumours, and tailor treatments to individual patients, which can make life better for them. This could lead to a new approach in cancer care.in cancer treatment.http://www.sciencedirect.com/science/article/pii/S2790676025000068ChemotherapyRadiation therapyDrug resistancePersonalized medicineAnd imaging agents |
| spellingShingle | Karthikeyan Elumalai Sivaneswari Srinivasan Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation Nano TransMed Chemotherapy Radiation therapy Drug resistance Personalized medicine And imaging agents |
| title | Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation |
| title_full | Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation |
| title_fullStr | Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation |
| title_full_unstemmed | Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation |
| title_short | Harnessing nanoparticle technology for precision medicine in head and neck cancer: Targeted delivery, immunomodulation, and clinical translation |
| title_sort | harnessing nanoparticle technology for precision medicine in head and neck cancer targeted delivery immunomodulation and clinical translation |
| topic | Chemotherapy Radiation therapy Drug resistance Personalized medicine And imaging agents |
| url | http://www.sciencedirect.com/science/article/pii/S2790676025000068 |
| work_keys_str_mv | AT karthikeyanelumalai harnessingnanoparticletechnologyforprecisionmedicineinheadandneckcancertargeteddeliveryimmunomodulationandclinicaltranslation AT sivaneswarisrinivasan harnessingnanoparticletechnologyforprecisionmedicineinheadandneckcancertargeteddeliveryimmunomodulationandclinicaltranslation |