Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities

Attenuated sex-related DNA methylation differences in cancer highlight the magnitude bias mediating existing disparities

Abstract Background DNA methylation (DNAm) influences both sex differences and cancer development, yet the mechanisms connecting these factors remain unclear. Methods Utilizing data from The Cancer Genome Atlas, we conducted a comprehensive analysis of sex-related DNAm effects in nine non-reproducti...

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Bibliographic Details
Main Authors: Jiaqi Zhou, Miao Li, Yu Chen, Shangzi Wang, Danke Wang, Chen Suo, Xingdong Chen
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Biology of Sex Differences
Subjects:
Sex differences
DNA methylation
Cancer
Gene expression
RNA-seq
Online Access:https://doi.org/10.1186/s13293-024-00682-4
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