Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age

Evaluating sex-specific responses to western diet across the lifespan: impact on cardiac function and transcriptomic signatures in C57BL/6J mice at 530 and 640/750 days of age

Abstract Background Long-term consumption of Western Diet (WD) is a well-established risk factor for the development of cardiovascular disease (CVD); however, there is a paucity of studies on the long-term effects of WD on the pathophysiology of CVD and sex-specific responses. Methods Our study aime...

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Main Authors: Ani Stepanyan, Agnieszka Brojakowska, Roksana Zakharyan, Siras Hakobyan, Suren Davitavyan, Tamara Sirunyan, Gisane Khachatryan, Mary K. Khlgatian, Malik Bisserier, Shihong Zhang, Susmita Sahoo, Lahouaria Hadri, Amit Rai, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A. Goukassian
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Cardiovascular Diabetology
Subjects:
Western Diet
Sex
Heart
Cardiovascular
RNA sequencing
Online Access:https://doi.org/10.1186/s12933-024-02565-9
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