Central Retinal Vein Occlusion with Therapeutic Level of Anticoagulation
Purpose. To describe a patient with two episodes of deep venous thrombosis and factor V Leiden mutation who presented with central retinal vein occlusion (CRVO) despite prophylactic use of warfarin sodium (Coumadin). Methods. A case report of a 44-year-old woman with a history of recurrent deep veno...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Case Reports in Medicine |
| Online Access: | http://dx.doi.org/10.1155/2009/827982 |
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| _version_ | 1832558622531387392 |
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| author | Sarwat Salim Wai-Ching Lam Wahid Hanna |
| author_facet | Sarwat Salim Wai-Ching Lam Wahid Hanna |
| author_sort | Sarwat Salim |
| collection | DOAJ |
| description | Purpose. To describe a patient with two episodes of deep venous thrombosis and factor V Leiden mutation who presented with central retinal vein occlusion (CRVO) despite prophylactic use of warfarin sodium (Coumadin). Methods. A case report of a 44-year-old woman with a history of recurrent deep venous thrombosis and Factor V Leiden mutation was placed on lifelong prophylactic therapy with warfarin. The patient presented with CRVO in the left eye despite therapeutic levels of warfarin. Results. Extensive systemic evaluation disclosed high titers for antinuclear antibody (ANA). Conclusion. Systemic anticoagulation with warfarin may not preclude further thrombotic episodes. In younger patients presenting with retinal vein occlusion and pre-existing multiple thrombophilic risk factors, a multidisciplinary approach is recommended to explore other therapeutic options to avoid further thromboembolic complications. |
| format | Article |
| id | doaj-art-daf94c0f0005403aaeac9df9e4d1be79 |
| institution | Kabale University |
| issn | 1687-9627 1687-9635 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Medicine |
| spelling | doaj-art-daf94c0f0005403aaeac9df9e4d1be792025-02-03T01:31:56ZengWileyCase Reports in Medicine1687-96271687-96352009-01-01200910.1155/2009/827982827982Central Retinal Vein Occlusion with Therapeutic Level of AnticoagulationSarwat Salim0Wai-Ching Lam1Wahid Hanna2Hamilton Eye Institute, University of Tennessee Health Science Center, 930 Madison Avenue, Memphis, TN 38163, USADepartment of Ophthalmology, University of Toronto, Toronto, ON, M5T 2S8, CanadaDepartment of Hematology, University of Tennessee, Knoxville, TN 37920, USAPurpose. To describe a patient with two episodes of deep venous thrombosis and factor V Leiden mutation who presented with central retinal vein occlusion (CRVO) despite prophylactic use of warfarin sodium (Coumadin). Methods. A case report of a 44-year-old woman with a history of recurrent deep venous thrombosis and Factor V Leiden mutation was placed on lifelong prophylactic therapy with warfarin. The patient presented with CRVO in the left eye despite therapeutic levels of warfarin. Results. Extensive systemic evaluation disclosed high titers for antinuclear antibody (ANA). Conclusion. Systemic anticoagulation with warfarin may not preclude further thrombotic episodes. In younger patients presenting with retinal vein occlusion and pre-existing multiple thrombophilic risk factors, a multidisciplinary approach is recommended to explore other therapeutic options to avoid further thromboembolic complications.http://dx.doi.org/10.1155/2009/827982 |
| spellingShingle | Sarwat Salim Wai-Ching Lam Wahid Hanna Central Retinal Vein Occlusion with Therapeutic Level of Anticoagulation Case Reports in Medicine |
| title | Central Retinal Vein Occlusion with Therapeutic Level of Anticoagulation |
| title_full | Central Retinal Vein Occlusion with Therapeutic Level of Anticoagulation |
| title_fullStr | Central Retinal Vein Occlusion with Therapeutic Level of Anticoagulation |
| title_full_unstemmed | Central Retinal Vein Occlusion with Therapeutic Level of Anticoagulation |
| title_short | Central Retinal Vein Occlusion with Therapeutic Level of Anticoagulation |
| title_sort | central retinal vein occlusion with therapeutic level of anticoagulation |
| url | http://dx.doi.org/10.1155/2009/827982 |
| work_keys_str_mv | AT sarwatsalim centralretinalveinocclusionwiththerapeuticlevelofanticoagulation AT waichinglam centralretinalveinocclusionwiththerapeuticlevelofanticoagulation AT wahidhanna centralretinalveinocclusionwiththerapeuticlevelofanticoagulation |