Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus
Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the nee...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Case Reports in Pediatrics |
| Online Access: | http://dx.doi.org/10.1155/2018/7654278 |
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| _version_ | 1850165979912339456 |
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| author | Ugochi O. Ogu Ghada Abusin Rolla F. Abu-Arja Janice M. Staber |
| author_facet | Ugochi O. Ogu Ghada Abusin Rolla F. Abu-Arja Janice M. Staber |
| author_sort | Ugochi O. Ogu |
| collection | DOAJ |
| description | Blue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free. |
| format | Article |
| id | doaj-art-daf82d5de6f249439ebe7dd842e9bf36 |
| institution | OA Journals |
| issn | 2090-6803 2090-6811 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pediatrics |
| spelling | doaj-art-daf82d5de6f249439ebe7dd842e9bf362025-08-20T02:21:35ZengWileyCase Reports in Pediatrics2090-68032090-68112018-01-01201810.1155/2018/76542787654278Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with SirolimusUgochi O. Ogu0Ghada Abusin1Rolla F. Abu-Arja2Janice M. Staber3Division of Hematology, Department of Oncology, Montefiore Medical Center, Bronx, NY, USADivision of Pediatric Hematology/Oncology, Department of Pediatrics, University of Michigan, Ann Arbor, MI, USADivision of Pediatric Hematology/Oncology/BMT, Nationwide Children’s Hospital, Columbus, OH, USADivision of Pediatric Hematology/Oncology, Stead Family Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, IA, USABlue rubber bleb nevus syndrome (BRBNS) is a rare disease with vascular malformations in several systems of the body, most commonly the skin and gastrointestinal tract. Bleeding from the gastrointestinal (GI) tract is a major complication, which may lead to chronic iron deficiency anemia and the need for frequent blood transfusions due to ongoing gastrointestinal blood loss. In this case report, we describe a now 19-year-old female with BRBNS who required six blood transfusions per year and after starting sirolimus is symptom- and transfusion-free.http://dx.doi.org/10.1155/2018/7654278 |
| spellingShingle | Ugochi O. Ogu Ghada Abusin Rolla F. Abu-Arja Janice M. Staber Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus Case Reports in Pediatrics |
| title | Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus |
| title_full | Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus |
| title_fullStr | Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus |
| title_full_unstemmed | Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus |
| title_short | Successful Management of Blue Rubber Bleb Nevus Syndrome (BRBNS) with Sirolimus |
| title_sort | successful management of blue rubber bleb nevus syndrome brbns with sirolimus |
| url | http://dx.doi.org/10.1155/2018/7654278 |
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