Redesigning error control in cross-linking mass spectrometry enables more robust and sensitive protein-protein interaction studies

Redesigning error control in cross-linking mass spectrometry enables more robust and sensitive protein-protein interaction studies

Abstract Cross-linking mass spectrometry (XL-MS) allows characterizing protein-protein interactions (PPIs) in native biological systems by capturing cross-links between different proteins (inter-links). However, inter-link identification remains challenging, requiring dedicated data filtering scheme...

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Bibliographic Details
Main Authors: Boris Bogdanow, Max Ruwolt, Julia Ruta, Lars Mühlberg, Cong Wang, Wen-feng Zeng, Arne Elofsson, Fan Liu
Format: Article
Language:English
Published: Springer Nature 2024-12-01
Series:Molecular Systems Biology
Subjects:
Cross-linking Mass Spectrometry
False-Discovery Rate
Proteomics
Structure Modeling
Error Control
Online Access:https://doi.org/10.1038/s44320-024-00079-w
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