ACL injury management: a comprehensive review of novel biotherapeutics
The anterior cruciate ligament (ACL) is integral to the stability of the knee joint, serving to limit anterior tibial translation and regulate rotational movements. ACL injuries are among the most common and debilitating forms of knee trauma, often resulting in joint effusion, muscular atrophy, and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1455225/full |
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| author | Xuezhi Yu Jiahui Hu Yifan Li Yu Wen Bin Li |
| author_facet | Xuezhi Yu Jiahui Hu Yifan Li Yu Wen Bin Li |
| author_sort | Xuezhi Yu |
| collection | DOAJ |
| description | The anterior cruciate ligament (ACL) is integral to the stability of the knee joint, serving to limit anterior tibial translation and regulate rotational movements. ACL injuries are among the most common and debilitating forms of knee trauma, often resulting in joint effusion, muscular atrophy, and diminished athletic capabilities. Despite the established efficacy of ACL reconstruction as the standard treatment, it is not uniformly successful. Consequently, there is a growing interest in novel biotherapeutic interventions as potential alternatives. This comprehensive review examines the latest advancements in ACL biotherapy, encompassing the application of hyaluronic acid, self-assembled short peptides, growth factors, stem cell therapy, gene therapy, platelet-rich plasma therapy, bone marrow aspirate concentrate cells, extracorporeal shock wave, electrical stimulation and cross bracing protocol. The collective aim of these innovative treatments is to facilitate the restoration of the ACL’s native biological and biomechanical integrity, with the ultimate goal of enhancing clinical outcomes and the functional recovery of affected individuals. |
| format | Article |
| id | doaj-art-daf4381f243b4fd38b8dacaf919aa933 |
| institution | Kabale University |
| issn | 2296-4185 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-daf4381f243b4fd38b8dacaf919aa9332025-08-20T03:53:42ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852024-11-011210.3389/fbioe.2024.14552251455225ACL injury management: a comprehensive review of novel biotherapeuticsXuezhi Yu0Jiahui Hu1Yifan Li2Yu Wen3Bin Li4Department of Joint Surgery and Sports Medicine, Shengjing Hospital, China Medical University, Shenyang, ChinaDepartment of Joint Surgery and Sports Medicine, Shengjing Hospital, China Medical University, Shenyang, ChinaDepartment of Histology and Embryology, College of Basic Medical Sciences, China Medical University, Shenyang, ChinaDepartment of Histology and Embryology, College of Basic Medical Sciences, China Medical University, Shenyang, ChinaDepartment of Joint Surgery and Sports Medicine, Shengjing Hospital, China Medical University, Shenyang, ChinaThe anterior cruciate ligament (ACL) is integral to the stability of the knee joint, serving to limit anterior tibial translation and regulate rotational movements. ACL injuries are among the most common and debilitating forms of knee trauma, often resulting in joint effusion, muscular atrophy, and diminished athletic capabilities. Despite the established efficacy of ACL reconstruction as the standard treatment, it is not uniformly successful. Consequently, there is a growing interest in novel biotherapeutic interventions as potential alternatives. This comprehensive review examines the latest advancements in ACL biotherapy, encompassing the application of hyaluronic acid, self-assembled short peptides, growth factors, stem cell therapy, gene therapy, platelet-rich plasma therapy, bone marrow aspirate concentrate cells, extracorporeal shock wave, electrical stimulation and cross bracing protocol. The collective aim of these innovative treatments is to facilitate the restoration of the ACL’s native biological and biomechanical integrity, with the ultimate goal of enhancing clinical outcomes and the functional recovery of affected individuals.https://www.frontiersin.org/articles/10.3389/fbioe.2024.1455225/fullACL injuryhyaluronic acidself-assembled peptidesgrowth factorsstem cellsgene therapy |
| spellingShingle | Xuezhi Yu Jiahui Hu Yifan Li Yu Wen Bin Li ACL injury management: a comprehensive review of novel biotherapeutics Frontiers in Bioengineering and Biotechnology ACL injury hyaluronic acid self-assembled peptides growth factors stem cells gene therapy |
| title | ACL injury management: a comprehensive review of novel biotherapeutics |
| title_full | ACL injury management: a comprehensive review of novel biotherapeutics |
| title_fullStr | ACL injury management: a comprehensive review of novel biotherapeutics |
| title_full_unstemmed | ACL injury management: a comprehensive review of novel biotherapeutics |
| title_short | ACL injury management: a comprehensive review of novel biotherapeutics |
| title_sort | acl injury management a comprehensive review of novel biotherapeutics |
| topic | ACL injury hyaluronic acid self-assembled peptides growth factors stem cells gene therapy |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2024.1455225/full |
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