SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis
SLC7A11: also known as Sodium-Coupled Neutral Amino Acid Transporter 11, is an essential transporter protein that plays a vital role in the intracellular transport of amino acids, especially cysteine. Recently, its involvement in cell death mechanisms has attracted considerable interest, underscorin...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1559423/full |
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| author | Wen-Wen Zhu Ying Liu Ze Yu Hong-Qiang Wang |
| author_facet | Wen-Wen Zhu Ying Liu Ze Yu Hong-Qiang Wang |
| author_sort | Wen-Wen Zhu |
| collection | DOAJ |
| description | SLC7A11: also known as Sodium-Coupled Neutral Amino Acid Transporter 11, is an essential transporter protein that plays a vital role in the intracellular transport of amino acids, especially cysteine. Recently, its involvement in cell death mechanisms has attracted considerable interest, underscoring its significance in both normal physiological functions and various disease states. This paper aims to provide a thorough overview of current understanding of the role of SLC7A11 in two specific types of cell death: disulfidptosis and ferroptosis. We highlight the dual functions of SLC7A11 in these processes, examining how its activity changes under different pathological conditions and what this means for potential therapeutic approaches. In this study, we clarify the regulatory mechanisms governing SLC7A11 and its influence on cell death, ultimately presenting new insights that could guide future research in targeted therapies. |
| format | Article |
| id | doaj-art-daf3fdfb46544cfbbcbab9a665e8f9aa |
| institution | DOAJ |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-daf3fdfb46544cfbbcbab9a665e8f9aa2025-08-20T03:19:52ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-06-011310.3389/fcell.2025.15594231559423SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosisWen-Wen Zhu0Ying Liu1Ze Yu2Hong-Qiang Wang3Cancer Chemotherapy Center, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, ChinaDepartment of pharmacy, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, ChinaThe laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, ChinaCancer Chemotherapy Center, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, ChinaSLC7A11: also known as Sodium-Coupled Neutral Amino Acid Transporter 11, is an essential transporter protein that plays a vital role in the intracellular transport of amino acids, especially cysteine. Recently, its involvement in cell death mechanisms has attracted considerable interest, underscoring its significance in both normal physiological functions and various disease states. This paper aims to provide a thorough overview of current understanding of the role of SLC7A11 in two specific types of cell death: disulfidptosis and ferroptosis. We highlight the dual functions of SLC7A11 in these processes, examining how its activity changes under different pathological conditions and what this means for potential therapeutic approaches. In this study, we clarify the regulatory mechanisms governing SLC7A11 and its influence on cell death, ultimately presenting new insights that could guide future research in targeted therapies.https://www.frontiersin.org/articles/10.3389/fcell.2025.1559423/fullSLC7A11disulfidptosisferroptosiscanceramino acid transport |
| spellingShingle | Wen-Wen Zhu Ying Liu Ze Yu Hong-Qiang Wang SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis Frontiers in Cell and Developmental Biology SLC7A11 disulfidptosis ferroptosis cancer amino acid transport |
| title | SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis |
| title_full | SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis |
| title_fullStr | SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis |
| title_full_unstemmed | SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis |
| title_short | SLC7A11-mediated cell death mechanism in cancer: a comparative study of disulfidptosis and ferroptosis |
| title_sort | slc7a11 mediated cell death mechanism in cancer a comparative study of disulfidptosis and ferroptosis |
| topic | SLC7A11 disulfidptosis ferroptosis cancer amino acid transport |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1559423/full |
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