Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical Study
Background: Apical periodontitis is a prevalent condition that necessitates effective intracanal medicaments for successful endodontic therapy. Materials and Methods: A randomized controlled clinical trial was conducted on 120 patients diagnosed with apical periodontitis. The patients were randomly...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of Pharmacy and Bioallied Sciences |
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| Online Access: | https://journals.lww.com/10.4103/jpbs.jpbs_1009_24 |
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| author | G. Priya Johnson Shruti Kataria Sravana Laxmi Penumaka Bilal Ameer Abdul Sattar Mohammed Sabari Murugesan |
| author_facet | G. Priya Johnson Shruti Kataria Sravana Laxmi Penumaka Bilal Ameer Abdul Sattar Mohammed Sabari Murugesan |
| author_sort | G. Priya Johnson |
| collection | DOAJ |
| description | Background:
Apical periodontitis is a prevalent condition that necessitates effective intracanal medicaments for successful endodontic therapy.
Materials and Methods:
A randomized controlled clinical trial was conducted on 120 patients diagnosed with apical periodontitis. The patients were randomly assigned to three groups, Group A (calcium hydroxide), Group B (triple antibiotic paste), and Group C (chlorhexidine gel), with 40 patients in each group. Each medicament was placed in the root canal after standard endodontic procedures, and the patients were evaluated at 1, 3, and 6 months using radiographic assessment and clinical examination. The primary outcome measure was the reduction in lesion size, and secondary outcomes included pain relief and healing time.
Results:
After 6 months, Group B (triple antibiotic paste) showed the highest reduction in lesion size, with an average decrease of 75%, followed by Group C (chlorhexidine gel), with a 60% reduction, and Group A (calcium hydroxide), with a 50% reduction. Pain relief was observed in 85% of patients in Group B, 75% in Group C, and 65% in Group A. The average healing time was the shortest in Group B (4 months), compared to Group C (5 months) and Group A (6 months).
Conclusion:
Triple antibiotic paste demonstrated superior efficacy in healing apical periodontitis compared to calcium hydroxide and chlorhexidine gel. |
| format | Article |
| id | doaj-art-daf3f98c547449b19c09792e92ec3f7c |
| institution | Kabale University |
| issn | 0976-4879 0975-7406 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj-art-daf3f98c547449b19c09792e92ec3f7c2025-01-13T09:54:13ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0976-48790975-74062024-12-0116Suppl 4S3503S350510.4103/jpbs.jpbs_1009_24Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical StudyG. Priya JohnsonShruti KatariaSravana Laxmi PenumakaBilal AmeerAbdul Sattar MohammedSabari MurugesanBackground: Apical periodontitis is a prevalent condition that necessitates effective intracanal medicaments for successful endodontic therapy. Materials and Methods: A randomized controlled clinical trial was conducted on 120 patients diagnosed with apical periodontitis. The patients were randomly assigned to three groups, Group A (calcium hydroxide), Group B (triple antibiotic paste), and Group C (chlorhexidine gel), with 40 patients in each group. Each medicament was placed in the root canal after standard endodontic procedures, and the patients were evaluated at 1, 3, and 6 months using radiographic assessment and clinical examination. The primary outcome measure was the reduction in lesion size, and secondary outcomes included pain relief and healing time. Results: After 6 months, Group B (triple antibiotic paste) showed the highest reduction in lesion size, with an average decrease of 75%, followed by Group C (chlorhexidine gel), with a 60% reduction, and Group A (calcium hydroxide), with a 50% reduction. Pain relief was observed in 85% of patients in Group B, 75% in Group C, and 65% in Group A. The average healing time was the shortest in Group B (4 months), compared to Group C (5 months) and Group A (6 months). Conclusion: Triple antibiotic paste demonstrated superior efficacy in healing apical periodontitis compared to calcium hydroxide and chlorhexidine gel.https://journals.lww.com/10.4103/jpbs.jpbs_1009_24apical periodontitiscalcium hydroxidechlorhexidine gelendodontic therapyintracanal medicamentslesion healingtriple antibiotic paste |
| spellingShingle | G. Priya Johnson Shruti Kataria Sravana Laxmi Penumaka Bilal Ameer Abdul Sattar Mohammed Sabari Murugesan Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical Study Journal of Pharmacy and Bioallied Sciences apical periodontitis calcium hydroxide chlorhexidine gel endodontic therapy intracanal medicaments lesion healing triple antibiotic paste |
| title | Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical Study |
| title_full | Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical Study |
| title_fullStr | Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical Study |
| title_full_unstemmed | Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical Study |
| title_short | Comparative Efficacy of Intracanal Medicaments in Healing Apical Periodontitis: Insights from a Comprehensive Clinical Study |
| title_sort | comparative efficacy of intracanal medicaments in healing apical periodontitis insights from a comprehensive clinical study |
| topic | apical periodontitis calcium hydroxide chlorhexidine gel endodontic therapy intracanal medicaments lesion healing triple antibiotic paste |
| url | https://journals.lww.com/10.4103/jpbs.jpbs_1009_24 |
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