Soluble α-Klotho Serum Levels in Chronic Kidney Disease

Soluble α-Klotho Serum Levels in Chronic Kidney Disease

Transmembrane α-Klotho (TM-Klotho), expressed in renal tubules, is a cofactor for FGF23-receptor. Circulating soluble-α-Klotho (s-Klotho) results from TM-Klotho shedding and acts on Phosphate (P) and Calcium (Ca) tubular transport. Decreased TM-Klotho, described in experimental chronic kidney diseas...

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Bibliographic Details
Main Authors: Silverio Rotondi, Marzia Pasquali, Lida Tartaglione, Maria Luisa Muci, Giusy Mandanici, Cristiana Leonangeli, Silvia Sales, Alessio Farcomeni, Sandro Mazzaferro
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:International Journal of Endocrinology
Online Access:http://dx.doi.org/10.1155/2015/872193
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