The skin I live in: Pathogenesis of white-nose syndrome of bats.
The emergence of white-nose syndrome (WNS) in North America has resulted in mass mortalities of hibernating bats and total extirpation of local populations. The need to mitigate this disease has stirred a significant body of research to understand its pathogenesis. Pseudogymnoascus destructans, the...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2024-08-01
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| Series: | PLoS Pathogens |
| Online Access: | https://doi.org/10.1371/journal.ppat.1012342 |
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| author | Marcos Isidoro-Ayza Jeffrey M Lorch Bruce S Klein |
| author_facet | Marcos Isidoro-Ayza Jeffrey M Lorch Bruce S Klein |
| author_sort | Marcos Isidoro-Ayza |
| collection | DOAJ |
| description | The emergence of white-nose syndrome (WNS) in North America has resulted in mass mortalities of hibernating bats and total extirpation of local populations. The need to mitigate this disease has stirred a significant body of research to understand its pathogenesis. Pseudogymnoascus destructans, the causative agent of WNS, is a psychrophilic (cold-loving) fungus that resides within the class Leotiomycetes, which contains mainly plant pathogens and is unrelated to other consequential pathogens of animals. In this review, we revisit the unique biology of hibernating bats and P. destructans and provide an updated analysis of the stages and mechanisms of WNS progression. The extreme life history of hibernating bats, the psychrophilic nature of P. destructans, and its evolutionary distance from other well-characterized animal-infecting fungi translate into unique host-pathogen interactions, many of them yet to be discovered. |
| format | Article |
| id | doaj-art-daec6b9c63d8451e80d444c9665dc90a |
| institution | Kabale University |
| issn | 1553-7366 1553-7374 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj-art-daec6b9c63d8451e80d444c9665dc90a2025-08-20T03:51:19ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742024-08-01208e101234210.1371/journal.ppat.1012342The skin I live in: Pathogenesis of white-nose syndrome of bats.Marcos Isidoro-AyzaJeffrey M LorchBruce S KleinThe emergence of white-nose syndrome (WNS) in North America has resulted in mass mortalities of hibernating bats and total extirpation of local populations. The need to mitigate this disease has stirred a significant body of research to understand its pathogenesis. Pseudogymnoascus destructans, the causative agent of WNS, is a psychrophilic (cold-loving) fungus that resides within the class Leotiomycetes, which contains mainly plant pathogens and is unrelated to other consequential pathogens of animals. In this review, we revisit the unique biology of hibernating bats and P. destructans and provide an updated analysis of the stages and mechanisms of WNS progression. The extreme life history of hibernating bats, the psychrophilic nature of P. destructans, and its evolutionary distance from other well-characterized animal-infecting fungi translate into unique host-pathogen interactions, many of them yet to be discovered.https://doi.org/10.1371/journal.ppat.1012342 |
| spellingShingle | Marcos Isidoro-Ayza Jeffrey M Lorch Bruce S Klein The skin I live in: Pathogenesis of white-nose syndrome of bats. PLoS Pathogens |
| title | The skin I live in: Pathogenesis of white-nose syndrome of bats. |
| title_full | The skin I live in: Pathogenesis of white-nose syndrome of bats. |
| title_fullStr | The skin I live in: Pathogenesis of white-nose syndrome of bats. |
| title_full_unstemmed | The skin I live in: Pathogenesis of white-nose syndrome of bats. |
| title_short | The skin I live in: Pathogenesis of white-nose syndrome of bats. |
| title_sort | skin i live in pathogenesis of white nose syndrome of bats |
| url | https://doi.org/10.1371/journal.ppat.1012342 |
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