FEMALE INFERTILITY ASSOCIATED WITH GENITAL TUBERCULOSIS

Analysis of the published reports indicates the alarming increase in prevalence of infertility that occurs in the current demographic situation and the unfavorable epidemiological trends in tuberculosis. At present, female genital tuberculosis (GT) is considered the cause of 10-27.8% of female infer...

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Main Authors: T. V. Klinyshkova, A. A. Yakovleva
Format: Article
Language:Russian
Published: IRBIS LLC 2018-05-01
Series:Акушерство, гинекология и репродукция
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Online Access:https://www.gynecology.su/jour/article/view/473
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author T. V. Klinyshkova
A. A. Yakovleva
author_facet T. V. Klinyshkova
A. A. Yakovleva
author_sort T. V. Klinyshkova
collection DOAJ
description Analysis of the published reports indicates the alarming increase in prevalence of infertility that occurs in the current demographic situation and the unfavorable epidemiological trends in tuberculosis. At present, female genital tuberculosis (GT) is considered the cause of 10-27.8% of female infertility cases and seen as a serious medical and social problem in women of reproductive age (24-35 years). Making a diagnosis of GT may become a complex task since: there are no commonly accepted schemes for the diagnostic procedure and patient management; the clinical manifestations of GT are nonspecific; the molecular-genetic, morphological, and microbiological diagnostic methods may not be sufficiently sensitive; the results of using hysterosalpingography are inconsistent (40-60% of discrepancies, high risk of complications); the indications to the Koch test and test-therapy are limited; the use of laparoscopy is still debatable; and the heterogeneity of the endoscopic picture in 13-59.7%  of suspected GT cases results in a low rate of confirmed GT – 9-26.3%. Immunological methods, in particular, the serological ones, take a lead in the diagnosis of extra-pulmonary tuberculosis. We propose that testing the local humoral immunity in women with infertility, along with the endoscopy, can improve the diagnosis of GT and avoid irreversible changes in the reproductive system.
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spelling doaj-art-dae7ecb712dc4eaf8d59728efee18af02025-08-20T03:19:14ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942018-05-01121748510.17749/2313-7347.2018.12.1.074-085443FEMALE INFERTILITY ASSOCIATED WITH GENITAL TUBERCULOSIST. V. Klinyshkova0A. A. Yakovleva1Omsk State Medical University, Health Ministry of Russian FederationClinic of Modern MedicineAnalysis of the published reports indicates the alarming increase in prevalence of infertility that occurs in the current demographic situation and the unfavorable epidemiological trends in tuberculosis. At present, female genital tuberculosis (GT) is considered the cause of 10-27.8% of female infertility cases and seen as a serious medical and social problem in women of reproductive age (24-35 years). Making a diagnosis of GT may become a complex task since: there are no commonly accepted schemes for the diagnostic procedure and patient management; the clinical manifestations of GT are nonspecific; the molecular-genetic, morphological, and microbiological diagnostic methods may not be sufficiently sensitive; the results of using hysterosalpingography are inconsistent (40-60% of discrepancies, high risk of complications); the indications to the Koch test and test-therapy are limited; the use of laparoscopy is still debatable; and the heterogeneity of the endoscopic picture in 13-59.7%  of suspected GT cases results in a low rate of confirmed GT – 9-26.3%. Immunological methods, in particular, the serological ones, take a lead in the diagnosis of extra-pulmonary tuberculosis. We propose that testing the local humoral immunity in women with infertility, along with the endoscopy, can improve the diagnosis of GT and avoid irreversible changes in the reproductive system.https://www.gynecology.su/jour/article/view/473infertilitygenital tuberculosisdiagnosticsmethods
spellingShingle T. V. Klinyshkova
A. A. Yakovleva
FEMALE INFERTILITY ASSOCIATED WITH GENITAL TUBERCULOSIS
Акушерство, гинекология и репродукция
infertility
genital tuberculosis
diagnostics
methods
title FEMALE INFERTILITY ASSOCIATED WITH GENITAL TUBERCULOSIS
title_full FEMALE INFERTILITY ASSOCIATED WITH GENITAL TUBERCULOSIS
title_fullStr FEMALE INFERTILITY ASSOCIATED WITH GENITAL TUBERCULOSIS
title_full_unstemmed FEMALE INFERTILITY ASSOCIATED WITH GENITAL TUBERCULOSIS
title_short FEMALE INFERTILITY ASSOCIATED WITH GENITAL TUBERCULOSIS
title_sort female infertility associated with genital tuberculosis
topic infertility
genital tuberculosis
diagnostics
methods
url https://www.gynecology.su/jour/article/view/473
work_keys_str_mv AT tvklinyshkova femaleinfertilityassociatedwithgenitaltuberculosis
AT aayakovleva femaleinfertilityassociatedwithgenitaltuberculosis