Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing
Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. Platinum-derived (Pt-derived) nanomateri...
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425004995 |
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| author | Jie Yang Qingyu Han Liping Li Ruiping Zhang |
| author_facet | Jie Yang Qingyu Han Liping Li Ruiping Zhang |
| author_sort | Jie Yang |
| collection | DOAJ |
| description | Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. Platinum-derived (Pt-derived) nanomaterials, owing to their distinctive biophysical characteristics and catalytic functionalities, have demonstrated promising therapeutic capabilities in chronic wound management. Nevertheless, critical gaps remain in understanding their clinical translation and effectiveness. In this context, the present review systematically investigated the structure-bioactivity relationships of Pt-derived nanocomposites and hybrid systems while evaluating their biomedical multivalency and combinatory approaches in therapeutic applications. In addition, the limitations currently impeding the practical implementation of Pt-derived nanotherapeutics and prospects for future advancements in material optimisation and biological integration strategies are addressed. |
| format | Article |
| id | doaj-art-dae4873e26cc4dafa936cad1093027fa |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-dae4873e26cc4dafa936cad1093027fa2025-08-20T03:20:22ZengElsevierMaterials Today Bio2590-00642025-06-013210192910.1016/j.mtbio.2025.101929Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healingJie Yang0Qingyu Han1Liping Li2Ruiping Zhang3Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, ChinaAcademy of Medical Sciences, Shanxi Medical University, Taiyuan, 030001, ChinaSchool of Basic Medical Sciences, Shanxi Medical University, Taiyuan, 030001, China; Corresponding author.The Radiology Department of Shanxi Provincial People’ Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, China; Corresponding author.Chronic wounds are a major public health concern worldwide because their complex pathophysiological processes and multifactorial etiology substantially complicate therapeutic interventions, highlighting the urgency of developing novel intervention approaches. Platinum-derived (Pt-derived) nanomaterials, owing to their distinctive biophysical characteristics and catalytic functionalities, have demonstrated promising therapeutic capabilities in chronic wound management. Nevertheless, critical gaps remain in understanding their clinical translation and effectiveness. In this context, the present review systematically investigated the structure-bioactivity relationships of Pt-derived nanocomposites and hybrid systems while evaluating their biomedical multivalency and combinatory approaches in therapeutic applications. In addition, the limitations currently impeding the practical implementation of Pt-derived nanotherapeutics and prospects for future advancements in material optimisation and biological integration strategies are addressed.http://www.sciencedirect.com/science/article/pii/S2590006425004995Pt-derived nanomaterialsChronic woundsVersatilityStructure-bioactivity relationshipsSynergistic strategyNanomedicine |
| spellingShingle | Jie Yang Qingyu Han Liping Li Ruiping Zhang Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing Materials Today Bio Pt-derived nanomaterials Chronic wounds Versatility Structure-bioactivity relationships Synergistic strategy Nanomedicine |
| title | Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing |
| title_full | Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing |
| title_fullStr | Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing |
| title_full_unstemmed | Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing |
| title_short | Innovative progress and clinical utilization of platinum-derived nanotherapeutics for chronic wound healing |
| title_sort | innovative progress and clinical utilization of platinum derived nanotherapeutics for chronic wound healing |
| topic | Pt-derived nanomaterials Chronic wounds Versatility Structure-bioactivity relationships Synergistic strategy Nanomedicine |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425004995 |
| work_keys_str_mv | AT jieyang innovativeprogressandclinicalutilizationofplatinumderivednanotherapeuticsforchronicwoundhealing AT qingyuhan innovativeprogressandclinicalutilizationofplatinumderivednanotherapeuticsforchronicwoundhealing AT lipingli innovativeprogressandclinicalutilizationofplatinumderivednanotherapeuticsforchronicwoundhealing AT ruipingzhang innovativeprogressandclinicalutilizationofplatinumderivednanotherapeuticsforchronicwoundhealing |