Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome
Many drugs have been developed that are able to modulate the GABAergic system, which is involved in anxiety, depression, epilepsy, insomnia, and learning and memory. The recent observation that the GABAA receptor is underexpressed in the fragile X syndrome, an inherited mental retardation disorder,...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2010.211 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832550773523742720 |
|---|---|
| author | Inge Heulens Charlotte D'Hulst Sien Braat Liesbeth Rooms R. Frank Kooy |
| author_facet | Inge Heulens Charlotte D'Hulst Sien Braat Liesbeth Rooms R. Frank Kooy |
| author_sort | Inge Heulens |
| collection | DOAJ |
| description | Many drugs have been developed that are able to modulate the GABAergic system, which is involved in anxiety, depression, epilepsy, insomnia, and learning and memory. The recent observation that the GABAA receptor is underexpressed in the fragile X syndrome, an inherited mental retardation disorder, therefore raised hopes for targeted therapy of the disorder. This review summarizes the lines of evidence that demonstrate a malfunction of the GABAergic system. The GABAergic system clearly emerges as an attractive target for therapy of the fragile X syndrome, and thus provides an excellent example of how genetic research can lead to unique opportunities for treatment. |
| format | Article |
| id | doaj-art-dad7eb9435d943df90638ce765ff24ee |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-dad7eb9435d943df90638ce765ff24ee2025-02-03T06:05:52ZengWileyThe Scientific World Journal1537-744X2010-01-01102198220610.1100/tsw.2010.211Involvement and Therapeutic Potential of the GABAergic System in the Fragile X SyndromeInge Heulens0Charlotte D'Hulst1Sien Braat2Liesbeth Rooms3R. Frank Kooy4Department of Medical Genetics, University of Antwerp, BelgiumDepartment of Medical Genetics, University of Antwerp, BelgiumDepartment of Medical Genetics, University of Antwerp, BelgiumDepartment of Medical Genetics, University of Antwerp, BelgiumDepartment of Medical Genetics, University of Antwerp, BelgiumMany drugs have been developed that are able to modulate the GABAergic system, which is involved in anxiety, depression, epilepsy, insomnia, and learning and memory. The recent observation that the GABAA receptor is underexpressed in the fragile X syndrome, an inherited mental retardation disorder, therefore raised hopes for targeted therapy of the disorder. This review summarizes the lines of evidence that demonstrate a malfunction of the GABAergic system. The GABAergic system clearly emerges as an attractive target for therapy of the fragile X syndrome, and thus provides an excellent example of how genetic research can lead to unique opportunities for treatment.http://dx.doi.org/10.1100/tsw.2010.211 |
| spellingShingle | Inge Heulens Charlotte D'Hulst Sien Braat Liesbeth Rooms R. Frank Kooy Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome The Scientific World Journal |
| title | Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome |
| title_full | Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome |
| title_fullStr | Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome |
| title_full_unstemmed | Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome |
| title_short | Involvement and Therapeutic Potential of the GABAergic System in the Fragile X Syndrome |
| title_sort | involvement and therapeutic potential of the gabaergic system in the fragile x syndrome |
| url | http://dx.doi.org/10.1100/tsw.2010.211 |
| work_keys_str_mv | AT ingeheulens involvementandtherapeuticpotentialofthegabaergicsysteminthefragilexsyndrome AT charlottedhulst involvementandtherapeuticpotentialofthegabaergicsysteminthefragilexsyndrome AT sienbraat involvementandtherapeuticpotentialofthegabaergicsysteminthefragilexsyndrome AT liesbethrooms involvementandtherapeuticpotentialofthegabaergicsysteminthefragilexsyndrome AT rfrankkooy involvementandtherapeuticpotentialofthegabaergicsysteminthefragilexsyndrome |