Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy
Immunotherapies, including immune checkpoint inhibitors and chimeric antigen receptor-T cell therapies, depend heavily on a healthy and diverse gut microbiome for optimal efficacy. Dysbiosis, or an imbalance in gut microbial composition and function, can diminish immunotherapy responses by altering...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-04-01
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| Series: | Journal for ImmunoTherapy of Cancer |
| Online Access: | https://jitc.bmj.com/content/13/4/e011540.full |
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| author | Laurence Zitvogel Andrew A. Almonte |
| author_facet | Laurence Zitvogel Andrew A. Almonte |
| author_sort | Laurence Zitvogel |
| collection | DOAJ |
| description | Immunotherapies, including immune checkpoint inhibitors and chimeric antigen receptor-T cell therapies, depend heavily on a healthy and diverse gut microbiome for optimal efficacy. Dysbiosis, or an imbalance in gut microbial composition and function, can diminish immunotherapy responses by altering immune cell trafficking and metabolic output. Key microbial metabolites such as short-chain fatty acids and modified bile acids shape host immunity and influence T-cell function, while their disruption can foster an immunosuppressive microenvironment. Emerging strategies to restore a balanced microbiome and boost treatment outcomes include dietary interventions, supplementation with beneficial microbes, and fecal microbiota transplantation. Despite these advances, challenges remain in defining dysbiosis, identifying reliable biomarkers, and tailoring microbiota-centered interventions. Nevertheless, as our understanding evolves, the gut microbiome holds promise as an integral component of personalized cancer immunotherapy. |
| format | Article |
| id | doaj-art-dad197308ae1480eb339b6083110f2fa |
| institution | OA Journals |
| issn | 2051-1426 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Journal for ImmunoTherapy of Cancer |
| spelling | doaj-art-dad197308ae1480eb339b6083110f2fa2025-08-20T02:12:46ZengBMJ Publishing GroupJournal for ImmunoTherapy of Cancer2051-14262025-04-0113410.1136/jitc-2025-011540Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapyLaurence Zitvogel0Andrew A. Almonte11Gustave Roussy, Villejuif, Ile-de-France, France1 Clinicobiome, Gustave Roussy Cancer Campus, Villejuif, FranceImmunotherapies, including immune checkpoint inhibitors and chimeric antigen receptor-T cell therapies, depend heavily on a healthy and diverse gut microbiome for optimal efficacy. Dysbiosis, or an imbalance in gut microbial composition and function, can diminish immunotherapy responses by altering immune cell trafficking and metabolic output. Key microbial metabolites such as short-chain fatty acids and modified bile acids shape host immunity and influence T-cell function, while their disruption can foster an immunosuppressive microenvironment. Emerging strategies to restore a balanced microbiome and boost treatment outcomes include dietary interventions, supplementation with beneficial microbes, and fecal microbiota transplantation. Despite these advances, challenges remain in defining dysbiosis, identifying reliable biomarkers, and tailoring microbiota-centered interventions. Nevertheless, as our understanding evolves, the gut microbiome holds promise as an integral component of personalized cancer immunotherapy.https://jitc.bmj.com/content/13/4/e011540.full |
| spellingShingle | Laurence Zitvogel Andrew A. Almonte Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy Journal for ImmunoTherapy of Cancer |
| title | Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy |
| title_full | Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy |
| title_fullStr | Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy |
| title_full_unstemmed | Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy |
| title_short | Gut reactions: harnessing microbial metabolism to fuel next-generation cancer immunotherapy |
| title_sort | gut reactions harnessing microbial metabolism to fuel next generation cancer immunotherapy |
| url | https://jitc.bmj.com/content/13/4/e011540.full |
| work_keys_str_mv | AT laurencezitvogel gutreactionsharnessingmicrobialmetabolismtofuelnextgenerationcancerimmunotherapy AT andrewaalmonte gutreactionsharnessingmicrobialmetabolismtofuelnextgenerationcancerimmunotherapy |