Modelling and sensitivity analysis to control dengue through inclusion of genetically modified hybrid mosquitoes
Dengue fever, an ancient yet persistent global health threat transmitted by mosquitoes, remains difficult to control. Recent advances propose genetically modified hybrid mosquitoes as a novel intervention. This study focuses on two primary control strategies: the Sterile Insect Technique (SIT) and g...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
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| Series: | Mathematical and Computer Modelling of Dynamical Systems |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/13873954.2025.2500446 |
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| Summary: | Dengue fever, an ancient yet persistent global health threat transmitted by mosquitoes, remains difficult to control. Recent advances propose genetically modified hybrid mosquitoes as a novel intervention. This study focuses on two primary control strategies: the Sterile Insect Technique (SIT) and genetic sterilization. SIT involves releasing sterile male mosquitoes to reduce populations through unsuccessful mating, while genetic sterilization targets mosquito reproduction or virus transmission capabilities. In our proposed model, modified mosquitoes are included in the susceptible vector compartment, denoted as [Formula: see text]. Diagnosis and treatment are modeled with parameters [Formula: see text] and [Formula: see text]. Field and laboratory studies suggest these methods effectively reduce mosquito populations and dengue incidence. A mathematical model is developed to study this strategy’s impact, incorporating the basic reproduction number [Formula: see text] and equilibrium analysis. Numerical methods are used to assess system stability and compute sensitivity indices [Formula: see text], ultimately demonstrating the potential for effective dengue control. |
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| ISSN: | 1387-3954 1744-5051 |