Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry

Antibodies are a major component of adaptive immunity against invading pathogens. Here, we explore possibilities for an analytical approach to characterize the antigen-specific antibody repertoire directly from the secreted proteins in convalescent serum. This approach aims to perform simultaneous a...

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Bibliographic Details
Main Authors: Douwe Schulte, Marta Šiborová, Lukas Käll, Joost Snijder
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-04-01
Series:eLife
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Online Access:https://elifesciences.org/articles/101322
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