EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE
The possibility of applying sedimentation, centrifuge, and filtration techniques for concentration of F. tularensis 15 NIIEG suspensions obtained after submerged cultivation has been evaluated. It is established that realization of tangential ultrafiltration as part of technological process of live...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/418 |
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| author | D. N. Bibikov O. A. Volokh A. V. Komissarov Yu. I. Samokhvalova N. G. Avdeeva A. K. Nikiforov |
| author_facet | D. N. Bibikov O. A. Volokh A. V. Komissarov Yu. I. Samokhvalova N. G. Avdeeva A. K. Nikiforov |
| author_sort | D. N. Bibikov |
| collection | DOAJ |
| description | The possibility of applying sedimentation, centrifuge, and filtration techniques for concentration of F. tularensis 15 NIIEG suspensions obtained after submerged cultivation has been evaluated. It is established that realization of tangential ultrafiltration as part of technological process of live tularemia vaccine production is of distinct advantage. Characteristics of Francisella tularensis 15 NIIEG concentrate stored under different temperature/time-dependent conditions have also been studies. It is demonstrated that it is practical to preserve them at 4 °C within ≤6 days. |
| format | Article |
| id | doaj-art-dac8b1b6fd684bb7b5ff610230129920 |
| institution | DOAJ |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-dac8b1b6fd684bb7b5ff6102301299202025-08-20T02:54:18ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0102130133418EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINED. N. Bibikov0O. A. Volokh1A. V. Komissarov2Yu. I. Samokhvalova3N. G. Avdeeva4A. K. Nikiforov5Federal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human WelfareFederal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human WelfareFederal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human WelfareFederal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human WelfareFederal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human WelfareFederal Government Health Institution Russian Research Anti-Plague Institute «Microbe», Federal Service for Surveillance in the Sphere of Consumers Rights Protection and Human Welfare; Federal State Funded Educational Institution of Higher Postgraduate Education «N.I. Vavilov Saratov State Agrarian University», Ministry of Agriculture of the Russian FederationThe possibility of applying sedimentation, centrifuge, and filtration techniques for concentration of F. tularensis 15 NIIEG suspensions obtained after submerged cultivation has been evaluated. It is established that realization of tangential ultrafiltration as part of technological process of live tularemia vaccine production is of distinct advantage. Characteristics of Francisella tularensis 15 NIIEG concentrate stored under different temperature/time-dependent conditions have also been studies. It is demonstrated that it is practical to preserve them at 4 °C within ≤6 days.https://www.pharmjournal.ru/jour/article/view/418francisella tularensisconcentrationlive tularemia vaccine |
| spellingShingle | D. N. Bibikov O. A. Volokh A. V. Komissarov Yu. I. Samokhvalova N. G. Avdeeva A. K. Nikiforov EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE Разработка и регистрация лекарственных средств francisella tularensis concentration live tularemia vaccine |
| title | EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE |
| title_full | EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE |
| title_fullStr | EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE |
| title_full_unstemmed | EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE |
| title_short | EXPERIMENTAL EVALUATION OF THE METHODS FOR <i>FRANCISELLA TULARENSIS </i>15 NIIEG BIOMASS CONCENTRATION TO BE USED IN MANUFACTURING OF LIVE TULAREMIA VACCINE |
| title_sort | experimental evaluation of the methods for i francisella tularensis i 15 niieg biomass concentration to be used in manufacturing of live tularemia vaccine |
| topic | francisella tularensis concentration live tularemia vaccine |
| url | https://www.pharmjournal.ru/jour/article/view/418 |
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