Joint effects of temperature and humidity with PM2.5 on COPD
Abstract Background Particulate matter less than 2.5 microns in aerodynamic diameter (PM2.5) is a significant air pollutant known to adversely affect respiratory health and increase the incidence of chronic obstructive pulmonary disease (COPD). Furthermore, climate change exacerbates these impacts,...
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2025-02-01
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| Online Access: | https://doi.org/10.1186/s12889-025-21564-3 |
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| author | Huan Minh Tran Feng-Jen Tsai Yuan-Hung Wang Kang-Yun Lee Jer-Hwa Chang Chi-Li Chung Chien-Hua Tseng Chien-Ling Su Yuan-Chien Lin Tzu-Tao Chen Kuan-Yuan Chen Shu-Chuan Ho Feng-Ming Yang Sheng-Ming Wu Kian Fan Chung Kin-Fai Ho Kai-Jen Chuang Hsiao-Chi Chuang |
| author_facet | Huan Minh Tran Feng-Jen Tsai Yuan-Hung Wang Kang-Yun Lee Jer-Hwa Chang Chi-Li Chung Chien-Hua Tseng Chien-Ling Su Yuan-Chien Lin Tzu-Tao Chen Kuan-Yuan Chen Shu-Chuan Ho Feng-Ming Yang Sheng-Ming Wu Kian Fan Chung Kin-Fai Ho Kai-Jen Chuang Hsiao-Chi Chuang |
| author_sort | Huan Minh Tran |
| collection | DOAJ |
| description | Abstract Background Particulate matter less than 2.5 microns in aerodynamic diameter (PM2.5) is a significant air pollutant known to adversely affect respiratory health and increase the incidence of chronic obstructive pulmonary disease (COPD). Furthermore, climate change exacerbates these impacts, as extreme temperatures and relative humidity (RH) levels can intensify the effects of PM2.5. This study aims to examine the joint effects of PM2.5, temperature, and RH on the risk of COPD. Methods A case–control study was conducted among 1,828 participants from 2017 to 2022 (995 COPD patients and 833 controls). The radial basis function interpolation was utilized to estimate participants' individual mean and differences in PM2.5, temperature, and RH in 1-day, 7-day, and 1-month periods. Logistic regression models examined the associations of environmental exposures with the risk of COPD adjusting for confounders. Joint effects of PM2.5 by quartiles of temperature and RH were also examined. Results We observed that a 1 µg/m3 increase in PM2.5 7-day and 1-month mean was associated with a 1.05-fold and 1.06-fold increase in OR of COPD (p < 0.05). For temperature and RH, we observed U-shaped effects on OR for COPD with optimal temperatures identified as 21.2 °C, 23.8 °C, and 23.8 °C for 1-day, 7-day, and 1-month mean temperature, respectively, and optimal RH levels identified as 73.8%, 76.7%, and 75.4% for 1-day, 7-day, and 1-month mean RH, respectively (p < 0.05). The joint effect models show that high temperatures (> 23.5 °C) and both extremely low (69.3%) and high (80.9%) RH levels generally exacerbate the effects of PM2.5 on OR for COPD, especially over longer exposure durations. Conclusion The joint effects of PM2.5, temperature, and RH on the risk of COPD underscore the importance of air pollution control and comprehensive research to mitigate COPD risk in the context of climate change. |
| format | Article |
| id | doaj-art-dac76ad8bff44dad8b31c3322e1bd8e0 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-dac76ad8bff44dad8b31c3322e1bd8e02025-02-09T12:58:31ZengBMCBMC Public Health1471-24582025-02-0125111210.1186/s12889-025-21564-3Joint effects of temperature and humidity with PM2.5 on COPDHuan Minh Tran0Feng-Jen Tsai1Yuan-Hung Wang2Kang-Yun Lee3Jer-Hwa Chang4Chi-Li Chung5Chien-Hua Tseng6Chien-Ling Su7Yuan-Chien Lin8Tzu-Tao Chen9Kuan-Yuan Chen10Shu-Chuan Ho11Feng-Ming Yang12Sheng-Ming Wu13Kian Fan Chung14Kin-Fai Ho15Kai-Jen Chuang16Hsiao-Chi Chuang17College of Public Health, Program in Global Health and Health Security, Taipei Medical UniversityCollege of Public Health, Program in Global Health and Health Security, Taipei Medical UniversityGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical UniversityDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical UniversityInhalation Toxicology Research Lab (ITRL), School of Respiratory Therapy, College of Medicine, Taipei Medical UniversityInhalation Toxicology Research Lab (ITRL), School of Respiratory Therapy, College of Medicine, Taipei Medical UniversityDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical UniversityDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical UniversityDepartment of Civil Engineering, National Central UniversityGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical UniversityGraduate Institute of Clinical Medicine, College of Medicine, Taipei Medical UniversityDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical UniversityInhalation Toxicology Research Lab (ITRL), School of Respiratory Therapy, College of Medicine, Taipei Medical UniversityDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical UniversityNational Heart and Lung Institute, Imperial College LondonThe Jockey Club School of Public Health and Primary Care, The Chinese University of Hong KongSchool of Public Health, College of Public Health, Taipei Medical UniversityDivision of Pulmonary Medicine, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical UniversityAbstract Background Particulate matter less than 2.5 microns in aerodynamic diameter (PM2.5) is a significant air pollutant known to adversely affect respiratory health and increase the incidence of chronic obstructive pulmonary disease (COPD). Furthermore, climate change exacerbates these impacts, as extreme temperatures and relative humidity (RH) levels can intensify the effects of PM2.5. This study aims to examine the joint effects of PM2.5, temperature, and RH on the risk of COPD. Methods A case–control study was conducted among 1,828 participants from 2017 to 2022 (995 COPD patients and 833 controls). The radial basis function interpolation was utilized to estimate participants' individual mean and differences in PM2.5, temperature, and RH in 1-day, 7-day, and 1-month periods. Logistic regression models examined the associations of environmental exposures with the risk of COPD adjusting for confounders. Joint effects of PM2.5 by quartiles of temperature and RH were also examined. Results We observed that a 1 µg/m3 increase in PM2.5 7-day and 1-month mean was associated with a 1.05-fold and 1.06-fold increase in OR of COPD (p < 0.05). For temperature and RH, we observed U-shaped effects on OR for COPD with optimal temperatures identified as 21.2 °C, 23.8 °C, and 23.8 °C for 1-day, 7-day, and 1-month mean temperature, respectively, and optimal RH levels identified as 73.8%, 76.7%, and 75.4% for 1-day, 7-day, and 1-month mean RH, respectively (p < 0.05). The joint effect models show that high temperatures (> 23.5 °C) and both extremely low (69.3%) and high (80.9%) RH levels generally exacerbate the effects of PM2.5 on OR for COPD, especially over longer exposure durations. Conclusion The joint effects of PM2.5, temperature, and RH on the risk of COPD underscore the importance of air pollution control and comprehensive research to mitigate COPD risk in the context of climate change.https://doi.org/10.1186/s12889-025-21564-3COPDPM2.5Relative humidityShort-term exposureTemperature |
| spellingShingle | Huan Minh Tran Feng-Jen Tsai Yuan-Hung Wang Kang-Yun Lee Jer-Hwa Chang Chi-Li Chung Chien-Hua Tseng Chien-Ling Su Yuan-Chien Lin Tzu-Tao Chen Kuan-Yuan Chen Shu-Chuan Ho Feng-Ming Yang Sheng-Ming Wu Kian Fan Chung Kin-Fai Ho Kai-Jen Chuang Hsiao-Chi Chuang Joint effects of temperature and humidity with PM2.5 on COPD BMC Public Health COPD PM2.5 Relative humidity Short-term exposure Temperature |
| title | Joint effects of temperature and humidity with PM2.5 on COPD |
| title_full | Joint effects of temperature and humidity with PM2.5 on COPD |
| title_fullStr | Joint effects of temperature and humidity with PM2.5 on COPD |
| title_full_unstemmed | Joint effects of temperature and humidity with PM2.5 on COPD |
| title_short | Joint effects of temperature and humidity with PM2.5 on COPD |
| title_sort | joint effects of temperature and humidity with pm2 5 on copd |
| topic | COPD PM2.5 Relative humidity Short-term exposure Temperature |
| url | https://doi.org/10.1186/s12889-025-21564-3 |
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