Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort Study
Background Intellectual disability (ID) may be associated with an increased risk of diabetes mellitus (DM). However, evidence from longitudinal studies is scarce, particularly in Asian populations. Methods This retrospective cohort study used representative linked data from the Korea National Disabi...
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Korean Endocrine Society
2025-02-01
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| Series: | Endocrinology and Metabolism |
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| Online Access: | http://e-enm.org/upload/pdf/enm-2024-2126.pdf |
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| author | Hye Yeon Koo In Young Cho Yoo Jin Um Yong-Moon Mark Park Kyung Mee Kim Chung Eun Lee Kyungdo Han |
| author_facet | Hye Yeon Koo In Young Cho Yoo Jin Um Yong-Moon Mark Park Kyung Mee Kim Chung Eun Lee Kyungdo Han |
| author_sort | Hye Yeon Koo |
| collection | DOAJ |
| description | Background Intellectual disability (ID) may be associated with an increased risk of diabetes mellitus (DM). However, evidence from longitudinal studies is scarce, particularly in Asian populations. Methods This retrospective cohort study used representative linked data from the Korea National Disability Registration System and the National Health Insurance Service database. Adults (≥20 years) who received a national health examination in 2009 (3,385 individuals with ID and 3,463,604 individuals without ID) were included and followed until 2020. ID was identified using legal registration information. Incident DM was defined by prescription records with relevant diagnostic codes. Multivariable-adjusted Cox proportional hazards regression models were used to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) for DM risks in individuals with ID compared to those without ID. Results Over a mean follow-up of 9.8 years, incident DM occurred in 302 (8.9%) individuals with ID and 299,156 (8.4%) individuals without ID. Having ID was associated with increased DM risk (aHR, 1.38; 95% CI, 1.23 to 1.55). Sensitivity analysis confirmed a higher DM risk in individuals with ID (aHR, 1.39; 95% CI, 1.24 to 1.56) than those with other disabilities (aHR, 1.11; 95% CI, 1.10 to 1.13) or no disability (reference). Stratified analysis showed higher DM risk in non-hypertensive subjects (aHR, 1.63; 95% CI, 1.43 to 1.86) compared to hypertensive subjects (aHR, 1.00; 95% CI, 0.80 to 1.26; P for interaction <0.001). Conclusion Adults with ID have an increased risk of developing DM, highlighting the need for targeted public health strategies to promote DM prevention in this population. |
| format | Article |
| id | doaj-art-dabfc9200e8b4de181b812813bc99178 |
| institution | DOAJ |
| issn | 2093-596X 2093-5978 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Korean Endocrine Society |
| record_format | Article |
| series | Endocrinology and Metabolism |
| spelling | doaj-art-dabfc9200e8b4de181b812813bc991782025-08-20T03:04:26ZengKorean Endocrine SocietyEndocrinology and Metabolism2093-596X2093-59782025-02-0140110311110.3803/EnM.2024.21262555Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort StudyHye Yeon Koo0In Young Cho1Yoo Jin Um2Yong-Moon Mark Park3Kyung Mee Kim4Chung Eun Lee5Kyungdo Han6 Department of Family Medicine, Seoul National University Bundang Hospital, Seongnam, Korea Department of Family Medicine and Supportive Care Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Family Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, AR, USA Department of Social Welfare, Soongsil University, Seoul, Korea Department of Education, Sungshin Women’s University, Seoul, Korea Department of Statistics and Actuarial Science, Soongsil University, Seoul, KoreaBackground Intellectual disability (ID) may be associated with an increased risk of diabetes mellitus (DM). However, evidence from longitudinal studies is scarce, particularly in Asian populations. Methods This retrospective cohort study used representative linked data from the Korea National Disability Registration System and the National Health Insurance Service database. Adults (≥20 years) who received a national health examination in 2009 (3,385 individuals with ID and 3,463,604 individuals without ID) were included and followed until 2020. ID was identified using legal registration information. Incident DM was defined by prescription records with relevant diagnostic codes. Multivariable-adjusted Cox proportional hazards regression models were used to estimate the adjusted hazard ratio (aHR) and 95% confidence interval (CI) for DM risks in individuals with ID compared to those without ID. Results Over a mean follow-up of 9.8 years, incident DM occurred in 302 (8.9%) individuals with ID and 299,156 (8.4%) individuals without ID. Having ID was associated with increased DM risk (aHR, 1.38; 95% CI, 1.23 to 1.55). Sensitivity analysis confirmed a higher DM risk in individuals with ID (aHR, 1.39; 95% CI, 1.24 to 1.56) than those with other disabilities (aHR, 1.11; 95% CI, 1.10 to 1.13) or no disability (reference). Stratified analysis showed higher DM risk in non-hypertensive subjects (aHR, 1.63; 95% CI, 1.43 to 1.86) compared to hypertensive subjects (aHR, 1.00; 95% CI, 0.80 to 1.26; P for interaction <0.001). Conclusion Adults with ID have an increased risk of developing DM, highlighting the need for targeted public health strategies to promote DM prevention in this population.http://e-enm.org/upload/pdf/enm-2024-2126.pdfintellectual disabilitydiabetes mellitusdisability studypublic health |
| spellingShingle | Hye Yeon Koo In Young Cho Yoo Jin Um Yong-Moon Mark Park Kyung Mee Kim Chung Eun Lee Kyungdo Han Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort Study Endocrinology and Metabolism intellectual disability diabetes mellitus disability study public health |
| title | Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort Study |
| title_full | Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort Study |
| title_fullStr | Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort Study |
| title_full_unstemmed | Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort Study |
| title_short | Risk of Diabetes Mellitus in Adults with Intellectual Disabilities: A Nationwide Cohort Study |
| title_sort | risk of diabetes mellitus in adults with intellectual disabilities a nationwide cohort study |
| topic | intellectual disability diabetes mellitus disability study public health |
| url | http://e-enm.org/upload/pdf/enm-2024-2126.pdf |
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