Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study.
<h4>Background</h4>Patients with schizophrenia and other psychoses exhibit a wide range of neuropsychological deficits. An unresolved question concerns whether there are gender differences in cognitive performance.<h4>Methods</h4>Data were derived from a multi-centre populati...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0077318 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849724455070203904 |
|---|---|
| author | Jolanta Zanelli Kevin Morgan Paola Dazzan Craig Morgan Manuela Russo Izabela Pilecka Paul Fearon Arsime Demjaha Gill A Doody Peter B Jones Robin M Murray Abraham Reichenberg |
| author_facet | Jolanta Zanelli Kevin Morgan Paola Dazzan Craig Morgan Manuela Russo Izabela Pilecka Paul Fearon Arsime Demjaha Gill A Doody Peter B Jones Robin M Murray Abraham Reichenberg |
| author_sort | Jolanta Zanelli |
| collection | DOAJ |
| description | <h4>Background</h4>Patients with schizophrenia and other psychoses exhibit a wide range of neuropsychological deficits. An unresolved question concerns whether there are gender differences in cognitive performance.<h4>Methods</h4>Data were derived from a multi-centre population based case-control study of patients with first-episode psychosis. A neuropsychological test battery was administered to patients with a diagnosis of schizophrenia or schizoaffective disorder (N=70, 36% females), bipolar/mania (N=34, 60% females), depressive psychosis (N=36, 58% females) and healthy controls (N=148, 55% females). Generalized and specific cognitive deficits were compared.<h4>Results</h4>There was strong evidence for disorder-specific gender differences in neuropsychological performance. Males and females with schizophrenia showed similar pervasive neuropsychological impairments. In psychotic depressive disorder females performed worse than males across neuropsychological measures. Differences in neuropsychological performance between males and females with bipolar/manic disorder were restricted to language functions. Symptom severity did not contribute to the observed gender differences.<h4>Conclusions</h4>Early in the course of psychotic illness, gender related factors appear to moderate the severity of cognitive deficits in depressive psychosis and bipolar/mania patients. |
| format | Article |
| id | doaj-art-dabc329313a74da2985fd4f8257f276c |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-dabc329313a74da2985fd4f8257f276c2025-08-20T03:10:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-01810e7731810.1371/journal.pone.0077318Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study.Jolanta ZanelliKevin MorganPaola DazzanCraig MorganManuela RussoIzabela PileckaPaul FearonArsime DemjahaGill A DoodyPeter B JonesRobin M MurrayAbraham Reichenberg<h4>Background</h4>Patients with schizophrenia and other psychoses exhibit a wide range of neuropsychological deficits. An unresolved question concerns whether there are gender differences in cognitive performance.<h4>Methods</h4>Data were derived from a multi-centre population based case-control study of patients with first-episode psychosis. A neuropsychological test battery was administered to patients with a diagnosis of schizophrenia or schizoaffective disorder (N=70, 36% females), bipolar/mania (N=34, 60% females), depressive psychosis (N=36, 58% females) and healthy controls (N=148, 55% females). Generalized and specific cognitive deficits were compared.<h4>Results</h4>There was strong evidence for disorder-specific gender differences in neuropsychological performance. Males and females with schizophrenia showed similar pervasive neuropsychological impairments. In psychotic depressive disorder females performed worse than males across neuropsychological measures. Differences in neuropsychological performance between males and females with bipolar/manic disorder were restricted to language functions. Symptom severity did not contribute to the observed gender differences.<h4>Conclusions</h4>Early in the course of psychotic illness, gender related factors appear to moderate the severity of cognitive deficits in depressive psychosis and bipolar/mania patients.https://doi.org/10.1371/journal.pone.0077318 |
| spellingShingle | Jolanta Zanelli Kevin Morgan Paola Dazzan Craig Morgan Manuela Russo Izabela Pilecka Paul Fearon Arsime Demjaha Gill A Doody Peter B Jones Robin M Murray Abraham Reichenberg Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study. PLoS ONE |
| title | Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study. |
| title_full | Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study. |
| title_fullStr | Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study. |
| title_full_unstemmed | Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study. |
| title_short | Gender differences in neuropsychological performance across psychotic disorders--a multi-centre population based case-control study. |
| title_sort | gender differences in neuropsychological performance across psychotic disorders a multi centre population based case control study |
| url | https://doi.org/10.1371/journal.pone.0077318 |
| work_keys_str_mv | AT jolantazanelli genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT kevinmorgan genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT paoladazzan genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT craigmorgan genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT manuelarusso genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT izabelapilecka genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT paulfearon genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT arsimedemjaha genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT gilladoody genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT peterbjones genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT robinmmurray genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy AT abrahamreichenberg genderdifferencesinneuropsychologicalperformanceacrosspsychoticdisordersamulticentrepopulationbasedcasecontrolstudy |