Developing a new cleavable crosslinker reagent for in-cell crosslinking

Developing a new cleavable crosslinker reagent for in-cell crosslinking

Abstract Crosslinking mass spectrometry (XL-MS) is a powerful technology that recently emerged as an essential complementary tool for elucidating protein structures and mapping interactions within a protein network. Crosslinkers which are amenable to post-linking backbone cleavage simplify peptide i...

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Main Authors: Fränze Müller, Bogdan R. Brutiu, Iakovos Saridakis, Thomas Leischner, Micha J. Birklbauer, Manuel Matzinger, Mathias Madalinski, Thomas Lendl, Saad Shaaban, Viktoria Dorfer, Nuno Maulide, Karl Mechtler
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-025-01568-1
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