Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients
The aim of this study was to investigate the possible influence of different genotypes of the lead single nucleotide polymorphisms (SNPs) rs10917468 and rs12045440 in the CAPZB gene on the thyroid function in papillary thyroid carcinoma (PTC) and benign thyroid neoplasm (BN) patients. In the study,...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2015/250542 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552599064150016 |
|---|---|
| author | Shouhao Feng Shengli Lin Jidong Zou Yulong Wang Qinghai Ji Zhenghua Lv |
| author_facet | Shouhao Feng Shengli Lin Jidong Zou Yulong Wang Qinghai Ji Zhenghua Lv |
| author_sort | Shouhao Feng |
| collection | DOAJ |
| description | The aim of this study was to investigate the possible influence of different genotypes of the lead single nucleotide polymorphisms (SNPs) rs10917468 and rs12045440 in the CAPZB gene on the thyroid function in papillary thyroid carcinoma (PTC) and benign thyroid neoplasm (BN) patients. In the study, a significant association was detected between rs12045440 and serum TSH concentrations in thyroid tumor patients (p=0.001). After the adjustment of relevant covariates, the difference between the mean serum TSH levels in different genotypes of rs12045440 was still significant in the BN group (p=0.003) but was not significant in the PTC cases (p=0.115). No significant association of rs10917468 with TSH levels was found. The SNP rs12045440 was associated with the serum TSH concentrations in Chinese thyroid tumor patients, especially in benign thyroid tumor cases. |
| format | Article |
| id | doaj-art-daba7732d5b64b17b20adb1a38106e8f |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-daba7732d5b64b17b20adb1a38106e8f2025-02-03T05:58:25ZengWileyInternational Journal of Endocrinology1687-83371687-83452015-01-01201510.1155/2015/250542250542Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor PatientsShouhao Feng0Shengli Lin1Jidong Zou2Yulong Wang3Qinghai Ji4Zhenghua Lv5Department of Otorhinolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, ChinaDepartment of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Otorhinolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, ChinaDepartment of Head and Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Head and Neck Surgery, Cancer Hospital, Fudan University, Shanghai 200032, ChinaDepartment of Otorhinolaryngology-Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University, Jinan 250021, ChinaThe aim of this study was to investigate the possible influence of different genotypes of the lead single nucleotide polymorphisms (SNPs) rs10917468 and rs12045440 in the CAPZB gene on the thyroid function in papillary thyroid carcinoma (PTC) and benign thyroid neoplasm (BN) patients. In the study, a significant association was detected between rs12045440 and serum TSH concentrations in thyroid tumor patients (p=0.001). After the adjustment of relevant covariates, the difference between the mean serum TSH levels in different genotypes of rs12045440 was still significant in the BN group (p=0.003) but was not significant in the PTC cases (p=0.115). No significant association of rs10917468 with TSH levels was found. The SNP rs12045440 was associated with the serum TSH concentrations in Chinese thyroid tumor patients, especially in benign thyroid tumor cases.http://dx.doi.org/10.1155/2015/250542 |
| spellingShingle | Shouhao Feng Shengli Lin Jidong Zou Yulong Wang Qinghai Ji Zhenghua Lv Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients International Journal of Endocrinology |
| title | Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients |
| title_full | Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients |
| title_fullStr | Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients |
| title_full_unstemmed | Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients |
| title_short | Association between rs12045440 Polymorphism in the CAPZB Intron and Serum TSH Concentrations in Chinese Thyroid Tumor Patients |
| title_sort | association between rs12045440 polymorphism in the capzb intron and serum tsh concentrations in chinese thyroid tumor patients |
| url | http://dx.doi.org/10.1155/2015/250542 |
| work_keys_str_mv | AT shouhaofeng associationbetweenrs12045440polymorphisminthecapzbintronandserumtshconcentrationsinchinesethyroidtumorpatients AT shenglilin associationbetweenrs12045440polymorphisminthecapzbintronandserumtshconcentrationsinchinesethyroidtumorpatients AT jidongzou associationbetweenrs12045440polymorphisminthecapzbintronandserumtshconcentrationsinchinesethyroidtumorpatients AT yulongwang associationbetweenrs12045440polymorphisminthecapzbintronandserumtshconcentrationsinchinesethyroidtumorpatients AT qinghaiji associationbetweenrs12045440polymorphisminthecapzbintronandserumtshconcentrationsinchinesethyroidtumorpatients AT zhenghualv associationbetweenrs12045440polymorphisminthecapzbintronandserumtshconcentrationsinchinesethyroidtumorpatients |