Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge.

Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge.

Live-attenuated SIV vaccines (LAVs) have been the most effective to date in preventing or partially controlling infection by wild-type SIV in non-human primate models of HIV-1 transmission to women acting by mechanisms of protection that are not well understood. To gain insights into mechanisms of p...

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Main Authors: Arun K Sasikala-Appukuttan, Hyeon O Kim, Nikilyn J Kinzel, Jung Joo Hong, Anthony J Smith, Reece Wagstaff, Cavan Reilly, Michael Piatak, Jeffrey D Lifson, R Keith Reeves, R Paul Johnson, Ashley T Haase, Pamela J Skinner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0081623
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