Rheumatoid arthritis and bacterial infections
To study features of bacterial infections course in pts with rheumatoid arthritis (RA) and changes of laboratory measures after focus of infection sanation. Material and methods. 46 pts with definite rheumatoid arthritis were examined at the time of comorbid infection (Cl) detection and after infect...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2008-02-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/983 |
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| author | N L Prokopjeva N N Vesikova I M Marusenko V A Ryabkov |
| author_facet | N L Prokopjeva N N Vesikova I M Marusenko V A Ryabkov |
| author_sort | N L Prokopjeva |
| collection | DOAJ |
| description | To study features of bacterial infections course in pts with rheumatoid arthritis (RA) and changes of laboratory measures after focus of infection sanation. Material and methods. 46 pts with definite rheumatoid arthritis were examined at the time of comorbid infection (Cl) detection and after infection focus sanation. Bacteriological test with evaluation of flora sensitivity to antibiotics by disco-diffusion method was performed at baseline and after the course of antibacterial therapy to assess its efficacy. Hemogram, serum fibrinogen, rheumatoid factor, circulating immune complexes (CIC), C-reactive protein levels were assessed. Serum interleukin (IL) 1(3, IL6 and neopterin concentrations were examined by immune-enzyme assay in a part of pts. Typical clinical features of Cl were present in only 28 (60,9%) pts. 13 (28,3%) pts had fever, 12 (26,0%) — leukocytosis, 15 (32,6%) — changes of leucocyte populations. Some laboratory measures (thrombocytes, fibrinogen, CIC, neopterin levels) significantly decreased (p<0,05) after infection focus sanation without correction of disease modifying therapy. Cl quite often develop as asymptomatic processes most often in pts with high activity and can induce disturbances promoting appearance of endothelial dysfunction, atherothrombosis and reduction of life duration. So timely detection and proper sanation of infection focuses should be performed in pts with RA |
| format | Article |
| id | doaj-art-dab98b81a44342a8b6c0eb126adaefb9 |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2008-02-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-dab98b81a44342a8b6c0eb126adaefb92025-08-20T03:01:57ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922008-02-01461253010.14412/1995-4484-2008-850923Rheumatoid arthritis and bacterial infectionsN L ProkopjevaN N VesikovaI M MarusenkoV A RyabkovTo study features of bacterial infections course in pts with rheumatoid arthritis (RA) and changes of laboratory measures after focus of infection sanation. Material and methods. 46 pts with definite rheumatoid arthritis were examined at the time of comorbid infection (Cl) detection and after infection focus sanation. Bacteriological test with evaluation of flora sensitivity to antibiotics by disco-diffusion method was performed at baseline and after the course of antibacterial therapy to assess its efficacy. Hemogram, serum fibrinogen, rheumatoid factor, circulating immune complexes (CIC), C-reactive protein levels were assessed. Serum interleukin (IL) 1(3, IL6 and neopterin concentrations were examined by immune-enzyme assay in a part of pts. Typical clinical features of Cl were present in only 28 (60,9%) pts. 13 (28,3%) pts had fever, 12 (26,0%) — leukocytosis, 15 (32,6%) — changes of leucocyte populations. Some laboratory measures (thrombocytes, fibrinogen, CIC, neopterin levels) significantly decreased (p<0,05) after infection focus sanation without correction of disease modifying therapy. Cl quite often develop as asymptomatic processes most often in pts with high activity and can induce disturbances promoting appearance of endothelial dysfunction, atherothrombosis and reduction of life duration. So timely detection and proper sanation of infection focuses should be performed in pts with RAhttps://rsp.mediar-press.net/rsp/article/view/983rheumatoid arthritiscomorbid infectioninterleukinsneopterin |
| spellingShingle | N L Prokopjeva N N Vesikova I M Marusenko V A Ryabkov Rheumatoid arthritis and bacterial infections Научно-практическая ревматология rheumatoid arthritis comorbid infection interleukins neopterin |
| title | Rheumatoid arthritis and bacterial infections |
| title_full | Rheumatoid arthritis and bacterial infections |
| title_fullStr | Rheumatoid arthritis and bacterial infections |
| title_full_unstemmed | Rheumatoid arthritis and bacterial infections |
| title_short | Rheumatoid arthritis and bacterial infections |
| title_sort | rheumatoid arthritis and bacterial infections |
| topic | rheumatoid arthritis comorbid infection interleukins neopterin |
| url | https://rsp.mediar-press.net/rsp/article/view/983 |
| work_keys_str_mv | AT nlprokopjeva rheumatoidarthritisandbacterialinfections AT nnvesikova rheumatoidarthritisandbacterialinfections AT immarusenko rheumatoidarthritisandbacterialinfections AT varyabkov rheumatoidarthritisandbacterialinfections |