Extracorporeal multi-organ support: ECMO, CRRT, and hemoperfusion for acute alcohol intoxication with renal and respiratory failure
Introduction Acute alcohol intoxication can lead to severe complications, including acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), and systemic inflammatory response syndrome (SIRS). Conventional treatments often fail to stabilize critically ill patients, necessitating advanc...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2487211 |
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| _version_ | 1850144328356200448 |
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| author | Xiting Dang Shuzhi Lv Miao Huang Huini Fu |
| author_facet | Xiting Dang Shuzhi Lv Miao Huang Huini Fu |
| author_sort | Xiting Dang |
| collection | DOAJ |
| description | Introduction Acute alcohol intoxication can lead to severe complications, including acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), and systemic inflammatory response syndrome (SIRS). Conventional treatments often fail to stabilize critically ill patients, necessitating advanced extracorporeal life support. This study evaluates the effectiveness of extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy (CRRT) and hemoperfusion (HP) in managing multi-organ failure after acute alcohol intoxication.Methodology A critically ill patient with alcohol-induced esophageal perforation, ARDS, and AKI was treated with ECMO, CRRT, and HP after conventional therapies proved insufficient. CRRT was used for fluid management and renal support, while HP facilitated cytokine removal to mitigate inflammation. The clinical course was monitored using respiratory parameters, renal function markers, inflammatory cytokine levels, and hemodynamic stability.Results The combination therapy improved oxygenation, stabilized renal function, and reduced systemic inflammation. The patient successfully underwent surgical repair for esophageal perforation and showed full recovery at two-year follow-up.Conclusion Integrating CRRT and HP into ECMO circuits offers a novel and effective approach for managing renal dysfunction in acute alcohol intoxication. This strategy may improve outcomes in critically ill patients requiring extracorporeal support. Further studies are needed to optimize its clinical application. |
| format | Article |
| id | doaj-art-dab934ffc88f4c38948577b80c4c2ea2 |
| institution | OA Journals |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-dab934ffc88f4c38948577b80c4c2ea22025-08-20T02:28:24ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492025-12-0147110.1080/0886022X.2025.2487211Extracorporeal multi-organ support: ECMO, CRRT, and hemoperfusion for acute alcohol intoxication with renal and respiratory failureXiting Dang0Shuzhi Lv1Miao Huang2Huini Fu3Department of Emergency, Nanyang Second General Hospital, Nanyang, ChinaDepartment of Cardiovascular Medicine, Nanyang Second General Hospital, Nanyang, ChinaDepartment of Emergency, Nanyang Second General Hospital, Nanyang, ChinaDepartment of Emergency, Nanyang Second General Hospital, Nanyang, ChinaIntroduction Acute alcohol intoxication can lead to severe complications, including acute kidney injury (AKI), acute respiratory distress syndrome (ARDS), and systemic inflammatory response syndrome (SIRS). Conventional treatments often fail to stabilize critically ill patients, necessitating advanced extracorporeal life support. This study evaluates the effectiveness of extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy (CRRT) and hemoperfusion (HP) in managing multi-organ failure after acute alcohol intoxication.Methodology A critically ill patient with alcohol-induced esophageal perforation, ARDS, and AKI was treated with ECMO, CRRT, and HP after conventional therapies proved insufficient. CRRT was used for fluid management and renal support, while HP facilitated cytokine removal to mitigate inflammation. The clinical course was monitored using respiratory parameters, renal function markers, inflammatory cytokine levels, and hemodynamic stability.Results The combination therapy improved oxygenation, stabilized renal function, and reduced systemic inflammation. The patient successfully underwent surgical repair for esophageal perforation and showed full recovery at two-year follow-up.Conclusion Integrating CRRT and HP into ECMO circuits offers a novel and effective approach for managing renal dysfunction in acute alcohol intoxication. This strategy may improve outcomes in critically ill patients requiring extracorporeal support. Further studies are needed to optimize its clinical application.https://www.tandfonline.com/doi/10.1080/0886022X.2025.2487211Extracorporeal membrane oxygenationcontinuous renal replacement therapyhemoperfusionacute alcohol intoxicationacute respiratory distress syndrome |
| spellingShingle | Xiting Dang Shuzhi Lv Miao Huang Huini Fu Extracorporeal multi-organ support: ECMO, CRRT, and hemoperfusion for acute alcohol intoxication with renal and respiratory failure Renal Failure Extracorporeal membrane oxygenation continuous renal replacement therapy hemoperfusion acute alcohol intoxication acute respiratory distress syndrome |
| title | Extracorporeal multi-organ support: ECMO, CRRT, and hemoperfusion for acute alcohol intoxication with renal and respiratory failure |
| title_full | Extracorporeal multi-organ support: ECMO, CRRT, and hemoperfusion for acute alcohol intoxication with renal and respiratory failure |
| title_fullStr | Extracorporeal multi-organ support: ECMO, CRRT, and hemoperfusion for acute alcohol intoxication with renal and respiratory failure |
| title_full_unstemmed | Extracorporeal multi-organ support: ECMO, CRRT, and hemoperfusion for acute alcohol intoxication with renal and respiratory failure |
| title_short | Extracorporeal multi-organ support: ECMO, CRRT, and hemoperfusion for acute alcohol intoxication with renal and respiratory failure |
| title_sort | extracorporeal multi organ support ecmo crrt and hemoperfusion for acute alcohol intoxication with renal and respiratory failure |
| topic | Extracorporeal membrane oxygenation continuous renal replacement therapy hemoperfusion acute alcohol intoxication acute respiratory distress syndrome |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2025.2487211 |
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