Histopathological, Histomorphometrical, and Radiographical Evaluation of Injectable Glass-Ceramic-Chitosan Nanocomposite in Bone Reconstruction of Rat
Background. Bone defects following tumor resection and osteolysis due to bone lesions, periodontal tissue disorders, and bone reconstruction are challenges that surgeons face. Gass-ceramic-chitosan nanocomposite contains chitosan, a derivative of crustaceans’ exoskeleton. Methods. Thirty-two 6–8-wee...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2015/719574 |
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| author | Maryam Seyedmajidi Seyedmahmood Rabiee Sina Haghanifar Seyedkamal Seyedmajidi Seyed Gholam ali Jorsaraei Homayoun Alaghehmand Naghmeh Jamaatlu Ali Bijani |
| author_facet | Maryam Seyedmajidi Seyedmahmood Rabiee Sina Haghanifar Seyedkamal Seyedmajidi Seyed Gholam ali Jorsaraei Homayoun Alaghehmand Naghmeh Jamaatlu Ali Bijani |
| author_sort | Maryam Seyedmajidi |
| collection | DOAJ |
| description | Background. Bone defects following tumor resection and osteolysis due to bone lesions, periodontal tissue disorders, and bone reconstruction are challenges that surgeons face. Gass-ceramic-chitosan nanocomposite contains chitosan, a derivative of crustaceans’ exoskeleton. Methods. Thirty-two 6–8-week-old male Wistar rats were chosen. One hole on each right and left tibia was made. The right tibia holes were filled with injectable glass-ceramic-chitosan nanocomposite, and the left tibia holes were left empty. After 7, 14, 28, and 60 days, histopathological, histomorphometrical, and radiographical assessments were performed. Results. Radiographic density on days 7 and 14 was significantly higher in the right tibias than in the left tibias. Trabecular bone thickness, which was higher in the right tibias, increased from day 7 to day 60 in both right and left tibias, although not significantly. Conclusions. Glass-ceramic-chitosan nanocomposite is suggested for use in bone repair in cases of bone loss. More histopathological, histomorphometrical, and radiographical assessments are also recommended. |
| format | Article |
| id | doaj-art-dab8d8655bf94f02afee7de1e251db2c |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-dab8d8655bf94f02afee7de1e251db2c2025-02-03T06:06:02ZengWileyInternational Journal of Biomaterials1687-87871687-87952015-01-01201510.1155/2015/719574719574Histopathological, Histomorphometrical, and Radiographical Evaluation of Injectable Glass-Ceramic-Chitosan Nanocomposite in Bone Reconstruction of RatMaryam Seyedmajidi0Seyedmahmood Rabiee1Sina Haghanifar2Seyedkamal Seyedmajidi3Seyed Gholam ali Jorsaraei4Homayoun Alaghehmand5Naghmeh Jamaatlu6Ali Bijani7Dental Materials Research Center, School of Dentistry, Babol University of Medical Sciences, Babol, IranDepartment of Materials Engineering, School of Mechanic Engineering, Babol University of Technology, Babol, IranOral & Maxillofacial Radiology Department, School of Dentistry, Babol University of Medical Sciences, Babol, IranDepartment of Materials Engineering, School of Mechanic Engineering, Babol University of Technology, Babol, IranFatemeh Zahra Infertility and Reproductive Health Research Center, School of Medicine, Babol University of Medical Sciences, Babol, IranOperative Dentistry Department, School of Dentistry, Babol University of Medical Sciences, Babol, IranDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, IranNon-communicable Pediatrics Disease Research Center, Babol University of Medical Sciences, Babol, IranBackground. Bone defects following tumor resection and osteolysis due to bone lesions, periodontal tissue disorders, and bone reconstruction are challenges that surgeons face. Gass-ceramic-chitosan nanocomposite contains chitosan, a derivative of crustaceans’ exoskeleton. Methods. Thirty-two 6–8-week-old male Wistar rats were chosen. One hole on each right and left tibia was made. The right tibia holes were filled with injectable glass-ceramic-chitosan nanocomposite, and the left tibia holes were left empty. After 7, 14, 28, and 60 days, histopathological, histomorphometrical, and radiographical assessments were performed. Results. Radiographic density on days 7 and 14 was significantly higher in the right tibias than in the left tibias. Trabecular bone thickness, which was higher in the right tibias, increased from day 7 to day 60 in both right and left tibias, although not significantly. Conclusions. Glass-ceramic-chitosan nanocomposite is suggested for use in bone repair in cases of bone loss. More histopathological, histomorphometrical, and radiographical assessments are also recommended.http://dx.doi.org/10.1155/2015/719574 |
| spellingShingle | Maryam Seyedmajidi Seyedmahmood Rabiee Sina Haghanifar Seyedkamal Seyedmajidi Seyed Gholam ali Jorsaraei Homayoun Alaghehmand Naghmeh Jamaatlu Ali Bijani Histopathological, Histomorphometrical, and Radiographical Evaluation of Injectable Glass-Ceramic-Chitosan Nanocomposite in Bone Reconstruction of Rat International Journal of Biomaterials |
| title | Histopathological, Histomorphometrical, and Radiographical Evaluation of Injectable Glass-Ceramic-Chitosan Nanocomposite in Bone Reconstruction of Rat |
| title_full | Histopathological, Histomorphometrical, and Radiographical Evaluation of Injectable Glass-Ceramic-Chitosan Nanocomposite in Bone Reconstruction of Rat |
| title_fullStr | Histopathological, Histomorphometrical, and Radiographical Evaluation of Injectable Glass-Ceramic-Chitosan Nanocomposite in Bone Reconstruction of Rat |
| title_full_unstemmed | Histopathological, Histomorphometrical, and Radiographical Evaluation of Injectable Glass-Ceramic-Chitosan Nanocomposite in Bone Reconstruction of Rat |
| title_short | Histopathological, Histomorphometrical, and Radiographical Evaluation of Injectable Glass-Ceramic-Chitosan Nanocomposite in Bone Reconstruction of Rat |
| title_sort | histopathological histomorphometrical and radiographical evaluation of injectable glass ceramic chitosan nanocomposite in bone reconstruction of rat |
| url | http://dx.doi.org/10.1155/2015/719574 |
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