The Angiotensin-Melatonin Axis
Accumulating evidence indicates that various biological and neuroendocrine circadian rhythms may be disrupted in cardiovascular and metabolic disorders. These circadian alterations may contribute to the progression of disease. Our studies direct to an important role of angiotensin II and melatonin i...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2013/521783 |
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| author | Luciana A. Campos Jose Cipolla-Neto Fernanda G. Amaral Lisete C. Michelini Michael Bader Ovidiu C. Baltatu |
| author_facet | Luciana A. Campos Jose Cipolla-Neto Fernanda G. Amaral Lisete C. Michelini Michael Bader Ovidiu C. Baltatu |
| author_sort | Luciana A. Campos |
| collection | DOAJ |
| description | Accumulating evidence indicates that various biological and neuroendocrine circadian rhythms may be disrupted in cardiovascular and metabolic disorders. These circadian alterations may contribute to the progression of disease. Our studies direct to an important role of angiotensin II and melatonin in the modulation of circadian rhythms. The brain renin-angiotensin system (RAS) may modulate melatonin synthesis, a hormone with well-established roles in regulating circadian rhythms. Angiotensin production in the central nervous system may not only influence hypertension but also appears to affect the circadian rhythm of blood pressure. Drugs acting on RAS have been proven effective in the treatment of cardiovascular and metabolic disorders including hypertension and diabetes mellitus (DM). On the other hand, since melatonin is capable of ameliorating metabolic abnormalities in DM and insulin resistance, the beneficial effects of RAS blockade could be improved through combined RAS blocker and melatonin therapy. Contemporary research is evidencing the existence of specific clock genes forming central and peripheral clocks governing circadian rhythms. Further research on the interaction between these two neurohormones and the clock genes governing circadian clocks may progress our understanding on the pathophysiology of disease with possible impact on chronotherapeutic strategies. |
| format | Article |
| id | doaj-art-dab62b2a8b154acd95ca9b15ef42a9c1 |
| institution | Kabale University |
| issn | 2090-0384 2090-0392 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-dab62b2a8b154acd95ca9b15ef42a9c12025-02-03T05:51:38ZengWileyInternational Journal of Hypertension2090-03842090-03922013-01-01201310.1155/2013/521783521783The Angiotensin-Melatonin AxisLuciana A. Campos0Jose Cipolla-Neto1Fernanda G. Amaral2Lisete C. Michelini3Michael Bader4Ovidiu C. Baltatu5Center of Innovation, Technology and Education—(CITE), Camilo Castelo Branco University (UNICASTELO), São José dos Campos Technology Park, Presidente Dutra Road Km 138, 12247-004 São José dos Campos, SP, BrazilDepartment of Physiology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, BrazilDepartment of Physiology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, BrazilDepartment of Physiology, Institute of Biomedical Sciences, University of São Paulo, 05508-000 São Paulo, SP, BrazilCardiovascular Research, Max Delbruck Center for Molecular Medicine, 13125 Berlin, GermanyCenter of Innovation, Technology and Education—(CITE), Camilo Castelo Branco University (UNICASTELO), São José dos Campos Technology Park, Presidente Dutra Road Km 138, 12247-004 São José dos Campos, SP, BrazilAccumulating evidence indicates that various biological and neuroendocrine circadian rhythms may be disrupted in cardiovascular and metabolic disorders. These circadian alterations may contribute to the progression of disease. Our studies direct to an important role of angiotensin II and melatonin in the modulation of circadian rhythms. The brain renin-angiotensin system (RAS) may modulate melatonin synthesis, a hormone with well-established roles in regulating circadian rhythms. Angiotensin production in the central nervous system may not only influence hypertension but also appears to affect the circadian rhythm of blood pressure. Drugs acting on RAS have been proven effective in the treatment of cardiovascular and metabolic disorders including hypertension and diabetes mellitus (DM). On the other hand, since melatonin is capable of ameliorating metabolic abnormalities in DM and insulin resistance, the beneficial effects of RAS blockade could be improved through combined RAS blocker and melatonin therapy. Contemporary research is evidencing the existence of specific clock genes forming central and peripheral clocks governing circadian rhythms. Further research on the interaction between these two neurohormones and the clock genes governing circadian clocks may progress our understanding on the pathophysiology of disease with possible impact on chronotherapeutic strategies.http://dx.doi.org/10.1155/2013/521783 |
| spellingShingle | Luciana A. Campos Jose Cipolla-Neto Fernanda G. Amaral Lisete C. Michelini Michael Bader Ovidiu C. Baltatu The Angiotensin-Melatonin Axis International Journal of Hypertension |
| title | The Angiotensin-Melatonin Axis |
| title_full | The Angiotensin-Melatonin Axis |
| title_fullStr | The Angiotensin-Melatonin Axis |
| title_full_unstemmed | The Angiotensin-Melatonin Axis |
| title_short | The Angiotensin-Melatonin Axis |
| title_sort | angiotensin melatonin axis |
| url | http://dx.doi.org/10.1155/2013/521783 |
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