Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation
Background. Thrombin has been implicated as a key molecule in atherosclerotic progression. Clinical evidence shows that thrombin generation is enhanced in atherosclerosis, but its role as a risk factor for coronary atherosclerotic burden has not been proven in coronary artery disease (CAD) stable pa...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Cardiology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/5149825 |
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| author | Benjamin Valente-Acosta Manuel Alfonso Baños-González Marco Antonio Peña-Duque Marco Antonio Martínez-Ríos Leslie Quintanar-Trejo Gad Aptilon-Duque Mirthala Flores-García David Cruz-Robles Guillermo Cardoso-Saldaña Aurora de la Peña-Díaz |
| author_facet | Benjamin Valente-Acosta Manuel Alfonso Baños-González Marco Antonio Peña-Duque Marco Antonio Martínez-Ríos Leslie Quintanar-Trejo Gad Aptilon-Duque Mirthala Flores-García David Cruz-Robles Guillermo Cardoso-Saldaña Aurora de la Peña-Díaz |
| author_sort | Benjamin Valente-Acosta |
| collection | DOAJ |
| description | Background. Thrombin has been implicated as a key molecule in atherosclerotic progression. Clinical evidence shows that thrombin generation is enhanced in atherosclerosis, but its role as a risk factor for coronary atherosclerotic burden has not been proven in coronary artery disease (CAD) stable patients. Objectives. To evaluate the association between TAT levels and homocysteine levels and the presence of coronary artery disease diagnosed by coronary angiography in patients with stable CAD. Methods and Results. We included 95 stable patients admitted to the Haemodynamics Department, including 63 patients with significant CAD and 32 patients without. We measured the thrombin-antithrombin complex (TAT) and homocysteine concentrations in all the patients. The CAD patients exhibited higher concentrations of TAT (40.76 μg/L versus 20.81 μg/L, p=0.002) and homocysteine (11.36 μmol/L versus 8.81 μmol/L, p<0.01) compared to the patients without significant CAD. Specifically, in patients with CAD+ the level of TAT level was associated with the severity of CAD being 36.17 ± 24.48 μg/L in the patients with bivascular obstruction and 42.77 ± 31.81 μg/L in trivascular coronary obstruction, p=0.002. Conclusions. The level of in vivo thrombin generation, quantified as TAT complexes, is associated with the presence and severity of CAD assessed by coronary angiography in stable CAD patients. |
| format | Article |
| id | doaj-art-dab2e04a8dc3462bbe0bc31c9112fec4 |
| institution | OA Journals |
| issn | 2090-8016 2090-0597 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cardiology Research and Practice |
| spelling | doaj-art-dab2e04a8dc3462bbe0bc31c9112fec42025-08-20T02:21:25ZengWileyCardiology Research and Practice2090-80162090-05972016-01-01201610.1155/2016/51498255149825Association between Stable Coronary Artery Disease and In Vivo Thrombin GenerationBenjamin Valente-Acosta0Manuel Alfonso Baños-González1Marco Antonio Peña-Duque2Marco Antonio Martínez-Ríos3Leslie Quintanar-Trejo4Gad Aptilon-Duque5Mirthala Flores-García6David Cruz-Robles7Guillermo Cardoso-Saldaña8Aurora de la Peña-Díaz9Instituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoInstituto Nacional de Cardiología Ignacio Chávez, Grupo Genética Intervencionista, Departamentos de Biología Molecular, Hemodinámica, Endocrinología, 14080 México City, MexicoBackground. Thrombin has been implicated as a key molecule in atherosclerotic progression. Clinical evidence shows that thrombin generation is enhanced in atherosclerosis, but its role as a risk factor for coronary atherosclerotic burden has not been proven in coronary artery disease (CAD) stable patients. Objectives. To evaluate the association between TAT levels and homocysteine levels and the presence of coronary artery disease diagnosed by coronary angiography in patients with stable CAD. Methods and Results. We included 95 stable patients admitted to the Haemodynamics Department, including 63 patients with significant CAD and 32 patients without. We measured the thrombin-antithrombin complex (TAT) and homocysteine concentrations in all the patients. The CAD patients exhibited higher concentrations of TAT (40.76 μg/L versus 20.81 μg/L, p=0.002) and homocysteine (11.36 μmol/L versus 8.81 μmol/L, p<0.01) compared to the patients without significant CAD. Specifically, in patients with CAD+ the level of TAT level was associated with the severity of CAD being 36.17 ± 24.48 μg/L in the patients with bivascular obstruction and 42.77 ± 31.81 μg/L in trivascular coronary obstruction, p=0.002. Conclusions. The level of in vivo thrombin generation, quantified as TAT complexes, is associated with the presence and severity of CAD assessed by coronary angiography in stable CAD patients.http://dx.doi.org/10.1155/2016/5149825 |
| spellingShingle | Benjamin Valente-Acosta Manuel Alfonso Baños-González Marco Antonio Peña-Duque Marco Antonio Martínez-Ríos Leslie Quintanar-Trejo Gad Aptilon-Duque Mirthala Flores-García David Cruz-Robles Guillermo Cardoso-Saldaña Aurora de la Peña-Díaz Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation Cardiology Research and Practice |
| title | Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation |
| title_full | Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation |
| title_fullStr | Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation |
| title_full_unstemmed | Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation |
| title_short | Association between Stable Coronary Artery Disease and In Vivo Thrombin Generation |
| title_sort | association between stable coronary artery disease and in vivo thrombin generation |
| url | http://dx.doi.org/10.1155/2016/5149825 |
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