Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice
We phylogenetically compared sequences of the zoonotic Lassa virus (LASV) obtained from Mastomys rodents in seven localities across the highly endemic Edo and Ondo States within Nigeria. Sequencing 1641 nt from the S segment of the virus genome, we resolved clades within lineage II that were either...
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2219350 |
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| author | Adetunji Samuel Adesina Akinlabi Oyeyiola Adeoba Obadare Joseph Igbokwe Chukwuyem Abejegah Patience Akhilomen Umaru Bangura Danny Asogun Ekaete Tobin Olufemi Ayodeji Omolaja Osoniyi Chris Davis Emma C. Thomson Meike Pahlmann Stephan Günther Elisabeth Fichet-Calvet Ayodeji Olayemi |
| author_facet | Adetunji Samuel Adesina Akinlabi Oyeyiola Adeoba Obadare Joseph Igbokwe Chukwuyem Abejegah Patience Akhilomen Umaru Bangura Danny Asogun Ekaete Tobin Olufemi Ayodeji Omolaja Osoniyi Chris Davis Emma C. Thomson Meike Pahlmann Stephan Günther Elisabeth Fichet-Calvet Ayodeji Olayemi |
| author_sort | Adetunji Samuel Adesina |
| collection | DOAJ |
| description | We phylogenetically compared sequences of the zoonotic Lassa virus (LASV) obtained from Mastomys rodents in seven localities across the highly endemic Edo and Ondo States within Nigeria. Sequencing 1641 nt from the S segment of the virus genome, we resolved clades within lineage II that were either limited to Ebudin and Okhuesan in Edo state (2g-beta) or along Owo-Okeluse-Ifon in Ondo state (2g-gamma). We also found clades within Ekpoma, a relatively large cosmopolitan town in Edo state, that extended into other localities within Edo (2g-alpha) and Ondo (2g-delta). LASV variants from M. natalensis within Ebudin and Ekpoma in Edo State (dated approximately 1961) were more ancient compared to those from Ondo state (approximately 1977), suggesting a broadly east-west virus migration across south-western Nigeria; a pattern not always consistent with LASV sequences derived from humans in the same localities. Additionally, in Ebudin and Ekpoma, LASV sequences between M. natalensis and M. erythroleucus were interspersed on the phylogenetic tree, but those from M. erythroleucus were estimated to emerge more recently (approximately 2005). Overall, our results show that LASV amplification in certain localities (reaching a prevalence as high as 76% in Okeluse), anthropogenically-aided spread of rodent-borne variants amidst the larger towns (involving communal accommodation such as student hostels), and virus-exchange between syntopic M. natalensis and M. erythroleucus rodents (as the latter, a savanna species, encroaches southward into the degraded forest) pose perpetual zoonotic hazard across the Edo-Ondo Lassa fever belt, threatening to accelerate the dissemination of the virus into non endemic areas. |
| format | Article |
| id | doaj-art-daae585ff4ff4b388bd75c191ef90d19 |
| institution | OA Journals |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
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| series | Emerging Microbes and Infections |
| spelling | doaj-art-daae585ff4ff4b388bd75c191ef90d192025-08-20T02:24:43ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2023.2219350Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate miceAdetunji Samuel Adesina0Akinlabi Oyeyiola1Adeoba Obadare2Joseph Igbokwe3Chukwuyem Abejegah4Patience Akhilomen5Umaru Bangura6Danny Asogun7Ekaete Tobin8Olufemi Ayodeji9Omolaja Osoniyi10Chris Davis11Emma C. Thomson12Meike Pahlmann13Stephan Günther14Elisabeth Fichet-Calvet15Ayodeji Olayemi16Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile Ife, Osun State, NigeriaNatural History Museum, Obafemi Awolowo University, Ile Ife, Osun State, NigeriaNatural History Museum, Obafemi Awolowo University, Ile Ife, Osun State, NigeriaDepartment of Zoology, Obafemi Awolowo University, Ile Ife, Osun State, NigeriaFederal Medical Centre, Owo, Ondo State, NigeriaIrrua Specialist Teaching Hospital, Irrua, Edo State, NigeriaBernhard Nocht Institute for Tropical Medicine, Hamburg, GermanyIrrua Specialist Teaching Hospital, Irrua, Edo State, NigeriaIrrua Specialist Teaching Hospital, Irrua, Edo State, NigeriaFederal Medical Centre, Owo, Ondo State, NigeriaDepartment of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile Ife, Osun State, NigeriaCentre for Virus Research, University of Glasgow, Glasgow, UKCentre for Virus Research, University of Glasgow, Glasgow, UKBernhard Nocht Institute for Tropical Medicine, Hamburg, GermanyBernhard Nocht Institute for Tropical Medicine, Hamburg, GermanyBernhard Nocht Institute for Tropical Medicine, Hamburg, GermanyNatural History Museum, Obafemi Awolowo University, Ile Ife, Osun State, NigeriaWe phylogenetically compared sequences of the zoonotic Lassa virus (LASV) obtained from Mastomys rodents in seven localities across the highly endemic Edo and Ondo States within Nigeria. Sequencing 1641 nt from the S segment of the virus genome, we resolved clades within lineage II that were either limited to Ebudin and Okhuesan in Edo state (2g-beta) or along Owo-Okeluse-Ifon in Ondo state (2g-gamma). We also found clades within Ekpoma, a relatively large cosmopolitan town in Edo state, that extended into other localities within Edo (2g-alpha) and Ondo (2g-delta). LASV variants from M. natalensis within Ebudin and Ekpoma in Edo State (dated approximately 1961) were more ancient compared to those from Ondo state (approximately 1977), suggesting a broadly east-west virus migration across south-western Nigeria; a pattern not always consistent with LASV sequences derived from humans in the same localities. Additionally, in Ebudin and Ekpoma, LASV sequences between M. natalensis and M. erythroleucus were interspersed on the phylogenetic tree, but those from M. erythroleucus were estimated to emerge more recently (approximately 2005). Overall, our results show that LASV amplification in certain localities (reaching a prevalence as high as 76% in Okeluse), anthropogenically-aided spread of rodent-borne variants amidst the larger towns (involving communal accommodation such as student hostels), and virus-exchange between syntopic M. natalensis and M. erythroleucus rodents (as the latter, a savanna species, encroaches southward into the degraded forest) pose perpetual zoonotic hazard across the Edo-Ondo Lassa fever belt, threatening to accelerate the dissemination of the virus into non endemic areas.https://www.tandfonline.com/doi/10.1080/22221751.2023.2219350Lassa virusMastomyshost-switchingemergence and spreadingNigeria |
| spellingShingle | Adetunji Samuel Adesina Akinlabi Oyeyiola Adeoba Obadare Joseph Igbokwe Chukwuyem Abejegah Patience Akhilomen Umaru Bangura Danny Asogun Ekaete Tobin Olufemi Ayodeji Omolaja Osoniyi Chris Davis Emma C. Thomson Meike Pahlmann Stephan Günther Elisabeth Fichet-Calvet Ayodeji Olayemi Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice Emerging Microbes and Infections Lassa virus Mastomys host-switching emergence and spreading Nigeria |
| title | Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice |
| title_full | Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice |
| title_fullStr | Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice |
| title_full_unstemmed | Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice |
| title_short | Circulation of Lassa virus across the endemic Edo-Ondo axis, Nigeria, with cross-species transmission between multimammate mice |
| title_sort | circulation of lassa virus across the endemic edo ondo axis nigeria with cross species transmission between multimammate mice |
| topic | Lassa virus Mastomys host-switching emergence and spreading Nigeria |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2219350 |
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