Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach
Breast cancer is one of the most common cancers in women all around the world and is a dominant cause of deaths occurring all around the globe. The available potent drugs for breast cancer show adverse effects and resistance and are found to be ineffective in patients. The high cost of curr...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Krupanidhi College of Pharmacy
2023-10-01
|
| Series: | Journal of Pharmaceutical Research |
| Online Access: | https://jopcr.com/articles/ligand-based-multi-targeted-molecular-docking-analysis-o-f-terpenoid-phytoconstituents-as-potential-chemotherapeutic-agents-against-breast-cancer-an-in-silico-approach |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849230195122241536 |
|---|---|
| author | Senthil Kumar Raju Shridharshini Kumar Praveen Sekar Naveena Sundhararajan Yogadharshini Nagalingam |
| author_facet | Senthil Kumar Raju Shridharshini Kumar Praveen Sekar Naveena Sundhararajan Yogadharshini Nagalingam |
| author_sort | Senthil Kumar Raju |
| collection | DOAJ |
| description | Breast cancer is one of the most common cancers in women all around the world and is a dominant cause of deaths occurring all around the globe. The available potent drugs for breast cancer show adverse effects and resistance and are found to be ineffective in patients. The high cost of currently available cancer therapy and certain limitations of current treatment make it necessary to search for novel, cost-effective and efficient methods of cancer treatment. Phytochemicals are directly involved in treatment or precursors to synthesize useful drugs. Therefore, in the current investigation, 500 terpenoid phytoconstituents and five proteins associated with breast cancer including EGFR, ERα, HER2, NF-κB and Topo IIa were selected from various databases. Selected compounds were screened for their molecular properties based on Lipinski's rule of five resulting in 235 compounds exclusion. Drug-likeness and PAINS alert properties were predicted using pkCSM and SwissADME web servers which led to the omission of 43 compounds. The remaining 222 compounds were screened to predict their ADMET properties and based on these results, 117 compounds were selected to predict the anti-breast cancer potential. Finally, 73 compounds, which showed anti-breast cancer activity prediction, were virtually screened and the top four best-scoring compounds were selected as lead-like molecules and docked with the five respective breast cancer targets. The results showed that the top four lead-like molecules exhibited greater binding affinity and lesser toxicity than the standard drugs namely 4–Hydroxytamoxifen, Daunorubicin, Erlotinib and Lapatinib. Keywords: ADMET, Breast cancer, Chemotherapeutic agents, In silico analysis, Molecular docking, Terpenoids |
| format | Article |
| id | doaj-art-daae5459e5e44908ac2279ac9def5641 |
| institution | Kabale University |
| issn | 0973-7200 2454-8405 |
| language | English |
| publishDate | 2023-10-01 |
| publisher | Krupanidhi College of Pharmacy |
| record_format | Article |
| series | Journal of Pharmaceutical Research |
| spelling | doaj-art-daae5459e5e44908ac2279ac9def56412025-08-21T09:34:09ZengKrupanidhi College of PharmacyJournal of Pharmaceutical Research0973-72002454-84052023-10-01222556210.18579/jopcr/v22.2.23.5Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico ApproachSenthil Kumar RajuShridharshini KumarPraveen SekarNaveena SundhararajanYogadharshini Nagalingam Breast cancer is one of the most common cancers in women all around the world and is a dominant cause of deaths occurring all around the globe. The available potent drugs for breast cancer show adverse effects and resistance and are found to be ineffective in patients. The high cost of currently available cancer therapy and certain limitations of current treatment make it necessary to search for novel, cost-effective and efficient methods of cancer treatment. Phytochemicals are directly involved in treatment or precursors to synthesize useful drugs. Therefore, in the current investigation, 500 terpenoid phytoconstituents and five proteins associated with breast cancer including EGFR, ERα, HER2, NF-κB and Topo IIa were selected from various databases. Selected compounds were screened for their molecular properties based on Lipinski's rule of five resulting in 235 compounds exclusion. Drug-likeness and PAINS alert properties were predicted using pkCSM and SwissADME web servers which led to the omission of 43 compounds. The remaining 222 compounds were screened to predict their ADMET properties and based on these results, 117 compounds were selected to predict the anti-breast cancer potential. Finally, 73 compounds, which showed anti-breast cancer activity prediction, were virtually screened and the top four best-scoring compounds were selected as lead-like molecules and docked with the five respective breast cancer targets. The results showed that the top four lead-like molecules exhibited greater binding affinity and lesser toxicity than the standard drugs namely 4–Hydroxytamoxifen, Daunorubicin, Erlotinib and Lapatinib. Keywords: ADMET, Breast cancer, Chemotherapeutic agents, In silico analysis, Molecular docking, Terpenoidshttps://jopcr.com/articles/ligand-based-multi-targeted-molecular-docking-analysis-o-f-terpenoid-phytoconstituents-as-potential-chemotherapeutic-agents-against-breast-cancer-an-in-silico-approach |
| spellingShingle | Senthil Kumar Raju Shridharshini Kumar Praveen Sekar Naveena Sundhararajan Yogadharshini Nagalingam Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach Journal of Pharmaceutical Research |
| title | Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach |
| title_full | Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach |
| title_fullStr | Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach |
| title_full_unstemmed | Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach |
| title_short | Ligand Based Multi-Targeted Molecular Docking Analysis o f Terpenoid Phytoconstituents as Potential Chemotherapeutic Agents Against Breast Cancer: An In Silico Approach |
| title_sort | ligand based multi targeted molecular docking analysis o f terpenoid phytoconstituents as potential chemotherapeutic agents against breast cancer an in silico approach |
| url | https://jopcr.com/articles/ligand-based-multi-targeted-molecular-docking-analysis-o-f-terpenoid-phytoconstituents-as-potential-chemotherapeutic-agents-against-breast-cancer-an-in-silico-approach |
| work_keys_str_mv | AT senthilkumarraju ligandbasedmultitargetedmoleculardockinganalysisofterpenoidphytoconstituentsaspotentialchemotherapeuticagentsagainstbreastcanceraninsilicoapproach AT shridharshinikumar ligandbasedmultitargetedmoleculardockinganalysisofterpenoidphytoconstituentsaspotentialchemotherapeuticagentsagainstbreastcanceraninsilicoapproach AT praveensekar ligandbasedmultitargetedmoleculardockinganalysisofterpenoidphytoconstituentsaspotentialchemotherapeuticagentsagainstbreastcanceraninsilicoapproach AT naveenasundhararajan ligandbasedmultitargetedmoleculardockinganalysisofterpenoidphytoconstituentsaspotentialchemotherapeuticagentsagainstbreastcanceraninsilicoapproach AT yogadharshininagalingam ligandbasedmultitargetedmoleculardockinganalysisofterpenoidphytoconstituentsaspotentialchemotherapeuticagentsagainstbreastcanceraninsilicoapproach |