Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region.
The Arabidopsis genome contains a large number of gene pairs that encode sense and antisense transcripts with overlapping 3' regions, indicative for a potential role of natural antisense transcription in regulating sense gene expression or transcript processing. When we mapped poly(A) transcrip...
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Public Library of Science (PLoS)
2011-02-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016769&type=printable |
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| author | Elena Zubko Andrea Kunova Peter Meyer |
| author_facet | Elena Zubko Andrea Kunova Peter Meyer |
| author_sort | Elena Zubko |
| collection | DOAJ |
| description | The Arabidopsis genome contains a large number of gene pairs that encode sense and antisense transcripts with overlapping 3' regions, indicative for a potential role of natural antisense transcription in regulating sense gene expression or transcript processing. When we mapped poly(A) transcripts of three plant gene pairs with long overlapping antisense transcripts, we identified an unusual transcript composition for two of the three gene pairs. Both genes pairs encoded a class of long sense transcripts and a class of short sense transcripts that terminate within the same polyadenylation region as the antisense transcripts encoded by the opposite strand. We find that the presence of the short sense transcript was not dependent on the expression of an antisense transcript. This argues against the assumption that the common termination region for sense and antisense poly(A) transcripts is the result of antisense-specific regulation. We speculate that for some genes evolution may have especially favoured alternative polyadenylation events that shorten transcript length for gene pairs with overlapping sense/antisense transcription, if this reduces the likelihood for dsRNA formation and transcript degradation. |
| format | Article |
| id | doaj-art-daa8d6a3354f4d99aa25cbade92a5413 |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2011-02-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-daa8d6a3354f4d99aa25cbade92a54132025-08-20T02:34:16ZengPublic Library of Science (PLoS)PLoS ONE1932-62032011-02-0162e1676910.1371/journal.pone.0016769Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region.Elena ZubkoAndrea KunovaPeter MeyerThe Arabidopsis genome contains a large number of gene pairs that encode sense and antisense transcripts with overlapping 3' regions, indicative for a potential role of natural antisense transcription in regulating sense gene expression or transcript processing. When we mapped poly(A) transcripts of three plant gene pairs with long overlapping antisense transcripts, we identified an unusual transcript composition for two of the three gene pairs. Both genes pairs encoded a class of long sense transcripts and a class of short sense transcripts that terminate within the same polyadenylation region as the antisense transcripts encoded by the opposite strand. We find that the presence of the short sense transcript was not dependent on the expression of an antisense transcript. This argues against the assumption that the common termination region for sense and antisense poly(A) transcripts is the result of antisense-specific regulation. We speculate that for some genes evolution may have especially favoured alternative polyadenylation events that shorten transcript length for gene pairs with overlapping sense/antisense transcription, if this reduces the likelihood for dsRNA formation and transcript degradation.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016769&type=printable |
| spellingShingle | Elena Zubko Andrea Kunova Peter Meyer Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region. PLoS ONE |
| title | Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region. |
| title_full | Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region. |
| title_fullStr | Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region. |
| title_full_unstemmed | Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region. |
| title_short | Sense and antisense transcripts of convergent gene pairs in Arabidopsis thaliana can share a common polyadenylation region. |
| title_sort | sense and antisense transcripts of convergent gene pairs in arabidopsis thaliana can share a common polyadenylation region |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0016769&type=printable |
| work_keys_str_mv | AT elenazubko senseandantisensetranscriptsofconvergentgenepairsinarabidopsisthalianacanshareacommonpolyadenylationregion AT andreakunova senseandantisensetranscriptsofconvergentgenepairsinarabidopsisthalianacanshareacommonpolyadenylationregion AT petermeyer senseandantisensetranscriptsofconvergentgenepairsinarabidopsisthalianacanshareacommonpolyadenylationregion |