Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein
A 48-year-old woman presented to our hospital with a 1-year history of a continuous high fever. She was diagnosed with metastatic pancreatic adenocarcinoma accompanied by leukocytosis without infection. Her serum concentration of granulocyte colony-stimulating factor was highly elevated. Forty-five...
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| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/5656130 |
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| author | Reiko Yamada Kyosuke Tanaka Hiroyuki Inoue Takashi Sakuno Tetsuro Harada Naohiko Yoshizawa Hiroshi Miura Toshihumi Takeuchi Misaki Nakamura Masaki Katsurahara Yasuhiko Hamada Noriyuki Horiki Yoshiyuki Takei |
| author_facet | Reiko Yamada Kyosuke Tanaka Hiroyuki Inoue Takashi Sakuno Tetsuro Harada Naohiko Yoshizawa Hiroshi Miura Toshihumi Takeuchi Misaki Nakamura Masaki Katsurahara Yasuhiko Hamada Noriyuki Horiki Yoshiyuki Takei |
| author_sort | Reiko Yamada |
| collection | DOAJ |
| description | A 48-year-old woman presented to our hospital with a 1-year history of a continuous high fever. She was diagnosed with metastatic pancreatic adenocarcinoma accompanied by leukocytosis without infection. Her serum concentration of granulocyte colony-stimulating factor was highly elevated. Forty-five days after initiating chemotherapy, she was readmitted because of a neuropsychiatric disturbance and hypercalcemia. Her serum concentration of parathyroid hormone-related protein (PTH-rP) was elevated. A pretreatment biopsy specimen showed strong cytoplasmic immunoreactivity to anti-PTH-rP antibody, suggesting that overproduction of PTH-rP accounted for the hypercalcemia. Although the patient regained consciousness after treatment, she died of progressive disease 60 days after chemotherapy. |
| format | Article |
| id | doaj-art-daa5400f122549319b8947568d82cea1 |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-daa5400f122549319b8947568d82cea12025-02-03T00:59:10ZengWileyCase Reports in Oncological Medicine2090-67062090-67142017-01-01201710.1155/2017/56561305656130Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related ProteinReiko Yamada0Kyosuke Tanaka1Hiroyuki Inoue2Takashi Sakuno3Tetsuro Harada4Naohiko Yoshizawa5Hiroshi Miura6Toshihumi Takeuchi7Misaki Nakamura8Masaki Katsurahara9Yasuhiko Hamada10Noriyuki Horiki11Yoshiyuki Takei12Department of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Endoscopy, Mie University School of Medicine, Tsu, JapanDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanDepartment of Endoscopy, Mie University School of Medicine, Tsu, JapanDepartment of Endoscopy, Mie University School of Medicine, Tsu, JapanDepartment of Endoscopy, Mie University School of Medicine, Tsu, JapanDepartment of Gastroenterology and Hepatology, Mie University Graduate School of Medicine, Tsu, JapanA 48-year-old woman presented to our hospital with a 1-year history of a continuous high fever. She was diagnosed with metastatic pancreatic adenocarcinoma accompanied by leukocytosis without infection. Her serum concentration of granulocyte colony-stimulating factor was highly elevated. Forty-five days after initiating chemotherapy, she was readmitted because of a neuropsychiatric disturbance and hypercalcemia. Her serum concentration of parathyroid hormone-related protein (PTH-rP) was elevated. A pretreatment biopsy specimen showed strong cytoplasmic immunoreactivity to anti-PTH-rP antibody, suggesting that overproduction of PTH-rP accounted for the hypercalcemia. Although the patient regained consciousness after treatment, she died of progressive disease 60 days after chemotherapy.http://dx.doi.org/10.1155/2017/5656130 |
| spellingShingle | Reiko Yamada Kyosuke Tanaka Hiroyuki Inoue Takashi Sakuno Tetsuro Harada Naohiko Yoshizawa Hiroshi Miura Toshihumi Takeuchi Misaki Nakamura Masaki Katsurahara Yasuhiko Hamada Noriyuki Horiki Yoshiyuki Takei Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein Case Reports in Oncological Medicine |
| title | Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein |
| title_full | Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein |
| title_fullStr | Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein |
| title_full_unstemmed | Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein |
| title_short | Pancreatic Adenocarcinoma Producing Parathyroid Hormone-Related Protein |
| title_sort | pancreatic adenocarcinoma producing parathyroid hormone related protein |
| url | http://dx.doi.org/10.1155/2017/5656130 |
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