Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study
Introduction. The study assessed the seroprevalence of Hepatitis E virus (HEV) markers in different at-risk groups within the Republic of Moldova. The risk groups included blood donors, hemodialysed patients, medical workers, tuberculosis (TB) patients, and intravenous drug users (IDUs). Material...
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Asociatia de Biosiguranta si Biosecuritate
2025-06-01
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| Series: | One Health & Risk Management |
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| Online Access: | https://www.journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/820 |
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| author | Octavian SAJIN Nina IZIUMOV Adela ȚURCANU Angela PARASCHIV Tiberiu HOLBAN Valentina BLAJ |
| author_facet | Octavian SAJIN Nina IZIUMOV Adela ȚURCANU Angela PARASCHIV Tiberiu HOLBAN Valentina BLAJ |
| author_sort | Octavian SAJIN |
| collection | DOAJ |
| description | Introduction. The study assessed the seroprevalence of Hepatitis E virus (HEV) markers in different at-risk groups within the Republic of Moldova. The risk groups included blood donors, hemodialysed patients, medical workers, tuberculosis (TB) patients, and intravenous drug users (IDUs).
Material and methods. A cross-sectional descriptive-epidemiological study was conducted from 2019 to 2023, with participants randomly selected from different risk groups. Blood samples were collected and tested using ELISA for Anti-HEV IgG and IgM markers. Seroprevalence was calculated with 95% confidence intervals, and statistical analyses were conducted using Epi Info 7.2 software.
Results. Among 794 tested blood donors, 9.6% (95% CI: 7.7-11.8) were positive for Anti-HEV IgG, indicating past exposure, and 8.3% (95% CI: 6.3-10.8) for Anti-HEV IgM, suggesting recent infection. Hemodialyzed patients had a significantly higher seroprevalence: 45.8% (95% CI: 34.8–57.1) for Anti-HEV IgG and 21.6% (95% CI: 9.8–38.2) for Anti-HEV IgM. Medical workers exhibited moderate IgG prevalence at 11.8% (95% CI: 9.1-15.0) and substantially higher IgM prevalence at 38.1% (95% CI: 26.1-51.2). TB patients had lower IgG (11.9%, 95% CI: 7.8-17.2) and IgM (7.8%, 95% CI: 3.6-14.3) prevalences. IDUs had a notable IgG prevalence of 20.5% (95% CI: 12.6-30.4) but no detectable IgM.
Conclusions. This study highlights the significant burden of hepatitis E virus infection among at-risk populations in the Republic of Moldova. |
| format | Article |
| id | doaj-art-daa44ed19b464dc2b8ec7a0417b56236 |
| institution | DOAJ |
| issn | 2587-3458 2587-3466 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Asociatia de Biosiguranta si Biosecuritate |
| record_format | Article |
| series | One Health & Risk Management |
| spelling | doaj-art-daa44ed19b464dc2b8ec7a0417b562362025-08-20T03:21:34ZengAsociatia de Biosiguranta si BiosecuritateOne Health & Risk Management2587-34582587-34662025-06-0162334410.38045/ohrm.2025.2.03Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional studyOctavian SAJIN0https://orcid.org/0009-0008-5458-6955Nina IZIUMOV1https://orcid.org/0009-0002-9988-9577Adela ȚURCANU2https://orcid.org/0000-0002-7684-1768Angela PARASCHIV3https://orcid.org/0000-0003-0817-8316Tiberiu HOLBAN4Valentina BLAJ5https://orcid.org/0009-0006-1554-7350National Agency for Public HealthNational Agency for Public HealthSUMP ”Nicolae Testemitanu”SUMP ”Nicolae Testemitanu”SUMP ”Nicolae Testemitanu”National Agency for Public HealthIntroduction. The study assessed the seroprevalence of Hepatitis E virus (HEV) markers in different at-risk groups within the Republic of Moldova. The risk groups included blood donors, hemodialysed patients, medical workers, tuberculosis (TB) patients, and intravenous drug users (IDUs). Material and methods. A cross-sectional descriptive-epidemiological study was conducted from 2019 to 2023, with participants randomly selected from different risk groups. Blood samples were collected and tested using ELISA for Anti-HEV IgG and IgM markers. Seroprevalence was calculated with 95% confidence intervals, and statistical analyses were conducted using Epi Info 7.2 software. Results. Among 794 tested blood donors, 9.6% (95% CI: 7.7-11.8) were positive for Anti-HEV IgG, indicating past exposure, and 8.3% (95% CI: 6.3-10.8) for Anti-HEV IgM, suggesting recent infection. Hemodialyzed patients had a significantly higher seroprevalence: 45.8% (95% CI: 34.8–57.1) for Anti-HEV IgG and 21.6% (95% CI: 9.8–38.2) for Anti-HEV IgM. Medical workers exhibited moderate IgG prevalence at 11.8% (95% CI: 9.1-15.0) and substantially higher IgM prevalence at 38.1% (95% CI: 26.1-51.2). TB patients had lower IgG (11.9%, 95% CI: 7.8-17.2) and IgM (7.8%, 95% CI: 3.6-14.3) prevalences. IDUs had a notable IgG prevalence of 20.5% (95% CI: 12.6-30.4) but no detectable IgM. Conclusions. This study highlights the significant burden of hepatitis E virus infection among at-risk populations in the Republic of Moldova.https://www.journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/820hepatitis e virusmoldovarisk groupsanti-hev antibodiesseroprevalence |
| spellingShingle | Octavian SAJIN Nina IZIUMOV Adela ȚURCANU Angela PARASCHIV Tiberiu HOLBAN Valentina BLAJ Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study One Health & Risk Management hepatitis e virus moldova risk groups anti-hev antibodies seroprevalence |
| title | Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study |
| title_full | Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study |
| title_fullStr | Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study |
| title_full_unstemmed | Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study |
| title_short | Seroprevalence of hepatitis e virus in five high-risk populations from the Republic of Moldova: a cross-sectional study |
| title_sort | seroprevalence of hepatitis e virus in five high risk populations from the republic of moldova a cross sectional study |
| topic | hepatitis e virus moldova risk groups anti-hev antibodies seroprevalence |
| url | https://www.journal.ohrm.bba.md/index.php/journal-ohrm-bba-md/article/view/820 |
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