Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study
Background: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine conditions that significantlyimpact the life quality of reproductive-aged women. In the Indian population, its prevalence varies from 3.7 to 22.5%depending on ethnicity and diagnostic criteria. Chronic inflammation p...
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Royan Institute (ACECR), Tehran
2025-01-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | https://www.ijfs.ir/article_713030_69703f6b96b80c3b7fe0073245f870ed.pdf |
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| author | Jijo Francis Honey Sebastian Saley Daniel Leyon Varghese Sareena Gilvaz Ragitha Thenkattil Sankarankutty Siji Susan George Pulikkottil Raphael Varghese Suresh Kumar Raveendran |
| author_facet | Jijo Francis Honey Sebastian Saley Daniel Leyon Varghese Sareena Gilvaz Ragitha Thenkattil Sankarankutty Siji Susan George Pulikkottil Raphael Varghese Suresh Kumar Raveendran |
| author_sort | Jijo Francis |
| collection | DOAJ |
| description | Background: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine conditions that significantlyimpact the life quality of reproductive-aged women. In the Indian population, its prevalence varies from 3.7 to 22.5%depending on ethnicity and diagnostic criteria. Chronic inflammation plays a pivotal role in PCOS pathogenesis.The monocyte chemoattractant protein-1 (MCP-1) is an important chemotactic factor for inflammatory response ofmonocytes. Genetic variations in the MCP-1 gene may modulate MCP-1 expression. Although the association of theMCP-1 promoter polymorphism (-2518A/G) was extensively studied in different inflammatory conditions, there isonly one report in PCOS conditions. Since no study was reported from the Indian population, we aimed to explore theassociation of the MCP-1 -2518A/G polymorphism (rs1024611) with PCOS.Materials and Methods: In this case-control study, to analyse the distribution and association of rs1024611 with PCOS,polymerase chain reaction-fragment length polymorphism (PCR-RFLP) analysis was carried out in 202 patients whoexhibited PCOS from menarche onwards or with higher severity of symptoms and 122 age-matched controls.Results: In our study, no significant correlation was observed in rs1024611 polymorphism with PCOS patients incomparison with control. In addition to this, we found no significant difference in the genotype and allele frequenciesbetween obese and non-obese PCOS patients.Conclusion: Our finding suggests that the MCP-1 -2518 A/G polymorphism has not been associated with PCOSpredisposition. |
| format | Article |
| id | doaj-art-daa1e6b8a4bf4f2cb476294606cfa482 |
| institution | Kabale University |
| issn | 2008-076X 2008-0778 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj-art-daa1e6b8a4bf4f2cb476294606cfa4822025-01-18T09:23:38ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782025-01-01191444910.22074/ijfs.2024.1974120.1406713030Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control StudyJijo Francis0Honey Sebastian1Saley Daniel2Leyon Varghese3Sareena Gilvaz4Ragitha Thenkattil Sankarankutty5Siji Susan George6Pulikkottil Raphael Varghese7Suresh Kumar Raveendran8Christ College (Autonomous), Irinjalakuda, Affiliated to the University of Calicut, Thrissur, Kerala, IndiaVimala College, Ramavarmapuram, University of Calicut, Thrissur, Kerala, IndiaDepartment of Gynaecology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaChrist College (Autonomous), Irinjalakuda, Affiliated to the University of Calicut, Thrissur, Kerala, IndiaDepartment of Gynaecology, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaJubilee Centre for Medical Research, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaNorthern Ontario School of Medicine, Ontario, CanadaJubilee Centre for Medical Research, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaJubilee Centre for Medical Research, Jubilee Mission Medical College and Research Institute, Thrissur, Kerala, IndiaBackground: Polycystic ovary syndrome (PCOS) is one of the most prevalent endocrine conditions that significantlyimpact the life quality of reproductive-aged women. In the Indian population, its prevalence varies from 3.7 to 22.5%depending on ethnicity and diagnostic criteria. Chronic inflammation plays a pivotal role in PCOS pathogenesis.The monocyte chemoattractant protein-1 (MCP-1) is an important chemotactic factor for inflammatory response ofmonocytes. Genetic variations in the MCP-1 gene may modulate MCP-1 expression. Although the association of theMCP-1 promoter polymorphism (-2518A/G) was extensively studied in different inflammatory conditions, there isonly one report in PCOS conditions. Since no study was reported from the Indian population, we aimed to explore theassociation of the MCP-1 -2518A/G polymorphism (rs1024611) with PCOS.Materials and Methods: In this case-control study, to analyse the distribution and association of rs1024611 with PCOS,polymerase chain reaction-fragment length polymorphism (PCR-RFLP) analysis was carried out in 202 patients whoexhibited PCOS from menarche onwards or with higher severity of symptoms and 122 age-matched controls.Results: In our study, no significant correlation was observed in rs1024611 polymorphism with PCOS patients incomparison with control. In addition to this, we found no significant difference in the genotype and allele frequenciesbetween obese and non-obese PCOS patients.Conclusion: Our finding suggests that the MCP-1 -2518 A/G polymorphism has not been associated with PCOSpredisposition.https://www.ijfs.ir/article_713030_69703f6b96b80c3b7fe0073245f870ed.pdfpolycystic ovary syndromepolymerase chain reaction-fragment length polymorphism-2518a/g polymorphism |
| spellingShingle | Jijo Francis Honey Sebastian Saley Daniel Leyon Varghese Sareena Gilvaz Ragitha Thenkattil Sankarankutty Siji Susan George Pulikkottil Raphael Varghese Suresh Kumar Raveendran Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study International Journal of Fertility and Sterility polycystic ovary syndrome polymerase chain reaction-fragment length polymorphism -2518a/g polymorphism |
| title | Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study |
| title_full | Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study |
| title_fullStr | Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study |
| title_full_unstemmed | Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study |
| title_short | Association of The MCP-1 rs1024611 Polymorphism with Polycystic Ovary Syndrome in A Population of Indian Women: A Case-Control Study |
| title_sort | association of the mcp 1 rs1024611 polymorphism with polycystic ovary syndrome in a population of indian women a case control study |
| topic | polycystic ovary syndrome polymerase chain reaction-fragment length polymorphism -2518a/g polymorphism |
| url | https://www.ijfs.ir/article_713030_69703f6b96b80c3b7fe0073245f870ed.pdf |
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