The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases
Abstract Autoimmune diseases are characterized by a dysfunction of the immune system. Disruptions in the balance of B-cell dynamics and the increase in auto-antibody levels are pivotal in the triggering of several autoimmune disorders. All of this is inextricably linked to the differentiation, devel...
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BMC
2025-04-01
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| Series: | Cell & Bioscience |
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| Online Access: | https://doi.org/10.1186/s13578-025-01398-7 |
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| author | Yongqi Shao Yang Mei Yixin Tan Ming Yang Haijing Wu |
| author_facet | Yongqi Shao Yang Mei Yixin Tan Ming Yang Haijing Wu |
| author_sort | Yongqi Shao |
| collection | DOAJ |
| description | Abstract Autoimmune diseases are characterized by a dysfunction of the immune system. Disruptions in the balance of B-cell dynamics and the increase in auto-antibody levels are pivotal in the triggering of several autoimmune disorders. All of this is inextricably linked to the differentiation, development, migration, and functional regulation of B cells in the human immune response. G protein-coupled receptors (GPCR) are recognized as crucial targets in drug development and play pivotal roles in both B cell differentiation and the underlying mechanisms of autoimmune diseases. However, there has been an inadequate comprehension of how GPCR intricately modulate B cell development and impact the pathogenesis of autoimmune diseases. Ligands and functions of GPCR—chemokine receptors including CXCR3, CXCR4, CXCR5 and CCR7, lipid receptors including S1PR1-5, cannabinoid receptor CB2 as well as orphan GPCR including GPR132, GPR183, GPR174, and P2RY8 in B cell differentiation and development, will be elaborated in this review. The roles these GPCR play in mediating B cells in several autoimmune diseases will also be discussed. The elucidation of the multifaceted mechanisms controlled by GPCR not only enriches our comprehension of immune responses but also provides a promising avenue for therapeutic interventions in the domain of autoimmune disorders. |
| format | Article |
| id | doaj-art-daa0328efde44ffba6e202afb6d531d3 |
| institution | DOAJ |
| issn | 2045-3701 |
| language | English |
| publishDate | 2025-04-01 |
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| series | Cell & Bioscience |
| spelling | doaj-art-daa0328efde44ffba6e202afb6d531d32025-08-20T02:55:24ZengBMCCell & Bioscience2045-37012025-04-0115111310.1186/s13578-025-01398-7The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseasesYongqi Shao0Yang Mei1Yixin Tan2Ming Yang3Haijing Wu4Department of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical EpigenomicsDepartment of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical EpigenomicsDepartment of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical EpigenomicsDepartment of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical EpigenomicsDepartment of Dermatology, Second Xiangya Hospital, Central South University, Hunan Key Laboratory of Medical EpigenomicsAbstract Autoimmune diseases are characterized by a dysfunction of the immune system. Disruptions in the balance of B-cell dynamics and the increase in auto-antibody levels are pivotal in the triggering of several autoimmune disorders. All of this is inextricably linked to the differentiation, development, migration, and functional regulation of B cells in the human immune response. G protein-coupled receptors (GPCR) are recognized as crucial targets in drug development and play pivotal roles in both B cell differentiation and the underlying mechanisms of autoimmune diseases. However, there has been an inadequate comprehension of how GPCR intricately modulate B cell development and impact the pathogenesis of autoimmune diseases. Ligands and functions of GPCR—chemokine receptors including CXCR3, CXCR4, CXCR5 and CCR7, lipid receptors including S1PR1-5, cannabinoid receptor CB2 as well as orphan GPCR including GPR132, GPR183, GPR174, and P2RY8 in B cell differentiation and development, will be elaborated in this review. The roles these GPCR play in mediating B cells in several autoimmune diseases will also be discussed. The elucidation of the multifaceted mechanisms controlled by GPCR not only enriches our comprehension of immune responses but also provides a promising avenue for therapeutic interventions in the domain of autoimmune disorders.https://doi.org/10.1186/s13578-025-01398-7G protein-coupled receptorsB cell differentiationAutoimmune diseases |
| spellingShingle | Yongqi Shao Yang Mei Yixin Tan Ming Yang Haijing Wu The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases Cell & Bioscience G protein-coupled receptors B cell differentiation Autoimmune diseases |
| title | The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases |
| title_full | The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases |
| title_fullStr | The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases |
| title_full_unstemmed | The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases |
| title_short | The regulatory functions of G protein-coupled receptors signaling pathways in B cell differentiation and development contributing to autoimmune diseases |
| title_sort | regulatory functions of g protein coupled receptors signaling pathways in b cell differentiation and development contributing to autoimmune diseases |
| topic | G protein-coupled receptors B cell differentiation Autoimmune diseases |
| url | https://doi.org/10.1186/s13578-025-01398-7 |
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