Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad
Objective: To determine the frequency of Helicobacter Pylori (H. Pylori) infection and its association with immune thrombocytopenia in patients presenting with dyspepsia symptoms. Study Design: Cross-sectional study. Place and Duration of Study. The study was conducted at the Department of General M...
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| Language: | English |
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National University of Medical Sciences
2025-01-01
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| Series: | Life and Science |
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| Online Access: | https://ojs.lifenscience.org/index.php/life-and-science/article/view/630 |
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| author | Mian Asif Mujtaba Hareema Saeed Khan Rimsha Azhar Amina Zulfiqar Shoukat Hussain Bukhari Asia Yousaf |
| author_facet | Mian Asif Mujtaba Hareema Saeed Khan Rimsha Azhar Amina Zulfiqar Shoukat Hussain Bukhari Asia Yousaf |
| author_sort | Mian Asif Mujtaba |
| collection | DOAJ |
| description | Objective: To determine the frequency of Helicobacter Pylori (H. Pylori) infection and its association with immune thrombocytopenia in patients presenting with dyspepsia symptoms.
Study Design: Cross-sectional study.
Place and Duration of Study. The study was conducted at the Department of General Medicine, Gastroenterology and Hematology, PIMS Islamabad, Pakistan, from 20th October 2019 to 20th April 2020.
Methods. A total of 275 patients with the symptoms of dyspepsia were enrolled. All patients of either sex or any age with the signs and symptoms of dyspepsia presenting through Gastro/Medicine OPD, wards, and emergency and admitted to hospital were included in the study. Those addicted to alcohol, on drugs (NSAIDS, Steroids) without PPI cover, chronic renal failure, and pregnancy were excluded from the study. The primary outcome was to determine frequency of helicobacter pylori infection in dyspeptic patients in our local settings.
Results: In this study, out of a total of 275 cases, females presented in dominance with 61% proportion. The average age of patients was 40 years, ranging from 44 to 95 years. The main presenting complaints were retrosternal burning (74.4%), bloating (65%), pain in the upper abdomen (49.6%), and water brash (37.9%). The frequency of helicobacter pylori infection confirmed on stool for helicobacter pylori antigen was (64.2%). 30.5% of patients have immune thrombocytopenia among those with stool for helicobacter pylori antigen positive.
Conclusion: Our findings validate previous reports on the association of helicobacter pylori infection with dyspepsia. In our study a high proportion of patients (64.2%) were having helicobacter pylori infection.
How to cite this: Mujtaba MA, khan HS, Azhar R, Zulfiqar A, Bukhari SH, Yousaf A. Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad. Life and Science. 2025; 6(1): 81-86. doi: http://doi.org/10.37185/LnS.1.1.630 |
| format | Article |
| id | doaj-art-da9b1c079453485b93ebab1ecb8ee57f |
| institution | DOAJ |
| issn | 2521-0475 2708-2970 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | National University of Medical Sciences |
| record_format | Article |
| series | Life and Science |
| spelling | doaj-art-da9b1c079453485b93ebab1ecb8ee57f2025-08-20T02:54:01ZengNational University of Medical SciencesLife and Science2521-04752708-29702025-01-0161060610.37185/LnS.1.1.630630Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, IslamabadMian Asif Mujtaba0Hareema Saeed Khan1Rimsha Azhar2Amina Zulfiqar3Shoukat Hussain Bukhari4Asia Yousaf5Federal Government Polyclinic Hospital Islamabad, PakistanFederal Government Polyclinic Hospital Islamabad, PakistanFederal Government Polyclinic Hospital Islamabad, PakistanFederal Government Polyclinic Hospital Islamabad, PakistanCDA Hospital Islamabad, PakistanPakistan Institute of Medical Sciences (PIMS) Islamabad, PakistanObjective: To determine the frequency of Helicobacter Pylori (H. Pylori) infection and its association with immune thrombocytopenia in patients presenting with dyspepsia symptoms. Study Design: Cross-sectional study. Place and Duration of Study. The study was conducted at the Department of General Medicine, Gastroenterology and Hematology, PIMS Islamabad, Pakistan, from 20th October 2019 to 20th April 2020. Methods. A total of 275 patients with the symptoms of dyspepsia were enrolled. All patients of either sex or any age with the signs and symptoms of dyspepsia presenting through Gastro/Medicine OPD, wards, and emergency and admitted to hospital were included in the study. Those addicted to alcohol, on drugs (NSAIDS, Steroids) without PPI cover, chronic renal failure, and pregnancy were excluded from the study. The primary outcome was to determine frequency of helicobacter pylori infection in dyspeptic patients in our local settings. Results: In this study, out of a total of 275 cases, females presented in dominance with 61% proportion. The average age of patients was 40 years, ranging from 44 to 95 years. The main presenting complaints were retrosternal burning (74.4%), bloating (65%), pain in the upper abdomen (49.6%), and water brash (37.9%). The frequency of helicobacter pylori infection confirmed on stool for helicobacter pylori antigen was (64.2%). 30.5% of patients have immune thrombocytopenia among those with stool for helicobacter pylori antigen positive. Conclusion: Our findings validate previous reports on the association of helicobacter pylori infection with dyspepsia. In our study a high proportion of patients (64.2%) were having helicobacter pylori infection. How to cite this: Mujtaba MA, khan HS, Azhar R, Zulfiqar A, Bukhari SH, Yousaf A. Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad. Life and Science. 2025; 6(1): 81-86. doi: http://doi.org/10.37185/LnS.1.1.630https://ojs.lifenscience.org/index.php/life-and-science/article/view/630dyspepsiahelicobacter-pylori infectionimmune thrombocytopenia |
| spellingShingle | Mian Asif Mujtaba Hareema Saeed Khan Rimsha Azhar Amina Zulfiqar Shoukat Hussain Bukhari Asia Yousaf Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad Life and Science dyspepsia helicobacter-pylori infection immune thrombocytopenia |
| title | Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad |
| title_full | Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad |
| title_fullStr | Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad |
| title_full_unstemmed | Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad |
| title_short | Frequency of Helicobacter Pylori Infections and Its Association with Immune Thrombocytopenia in Patients Presenting with Dyspepsia in Tertiary Care Setting, Islamabad |
| title_sort | frequency of helicobacter pylori infections and its association with immune thrombocytopenia in patients presenting with dyspepsia in tertiary care setting islamabad |
| topic | dyspepsia helicobacter-pylori infection immune thrombocytopenia |
| url | https://ojs.lifenscience.org/index.php/life-and-science/article/view/630 |
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