Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study
ABSTRACT Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk...
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| Format: | Article |
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Wiley
2025-01-01
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| Series: | The Journal of Clinical Hypertension |
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| Online Access: | https://doi.org/10.1111/jch.14939 |
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| author | Shaole Shi Fangyuan Wu Shanshan Zhao Zilian Wang Yongqiang Fan |
| author_facet | Shaole Shi Fangyuan Wu Shanshan Zhao Zilian Wang Yongqiang Fan |
| author_sort | Shaole Shi |
| collection | DOAJ |
| description | ABSTRACT Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease. |
| format | Article |
| id | doaj-art-da971c4cafb648a49a94ce7a98bd9cae |
| institution | Kabale University |
| issn | 1524-6175 1751-7176 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
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| series | The Journal of Clinical Hypertension |
| spelling | doaj-art-da971c4cafb648a49a94ce7a98bd9cae2025-01-31T05:38:37ZengWileyThe Journal of Clinical Hypertension1524-61751751-71762025-01-01271n/an/a10.1111/jch.14939Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization StudyShaole Shi0Fangyuan Wu1Shanshan Zhao2Zilian Wang3Yongqiang Fan4Department of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDivision of Hypertension and Vascular Diseases Department of Cardiology Heart Center The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDepartment of Obstetrics and Gynecology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou ChinaDepartment of Cardiology Donguan Songshan Lake Tungwah Hospital Dongguan ChinaABSTRACT Circulating lipids play a crucial role during pregnancy and may impact various pregnancy‐related diseases. This study employed a two‐sample Mendelian randomization (MR) framework to investigate the causal relationship between alterations in multidimensional plasma lipid levels and the risk of preeclampsia or eclampsia, offering deeper insight into this association. The inverse variance weighted (IVW) method was utilized as the main analysis. Summary statistics from plasma lipidomics of 7174 Finnish individuals and summary data on preeclampsia/eclampsia from the FinnGen consortium involving 219 817 European participants were employed. Sensitivity analyses were conducted to evaluate heterogeneity and pleiotropy. The study identified 17 lipid species from a total of 179 lipid species associated with susceptibility to preeclampsia/eclampsia. Notably, ten species, including six triacylglycerols (TAGs) (50:1, 48:1, 56:4, 49:2, 48:2, 54:3), a diacylglycerol (DAG) (16:1_18:1), and three sphingomyelins (SMs) (d36:1, d34:1, d38:1), were found to increase the risk of preeclampsia/eclampsia. Conversely, seven species, including five phosphatidylcholines (PCs) (16:1_20:4, O‐18:1_20:4, 18:1_20:4, 16:0_20:4, 17:0_20:4) and two phosphatidylethanolamines (PEAs) (18:0_20:4, 16:0_20:4), all containing arachidonic acid (ARA) in the sn‐2 position, were associated with a reduced risk of preeclampsia/eclampsia (all p < 0.05). The results of the stratified analysis were consistent with these findings. Furthermore, reverse MR analysis indicated that preeclampsia/eclampsia does not causally affect plasma levels of these lipids. Our findings established a causal relationship between specific plasma lipid species and modulation of preeclampsia/eclampsia risk, providing improved resolution for risk assessment and potential therapeutic targets in the disease.https://doi.org/10.1111/jch.14939eclampsiaMendelian randomizationplasma lipidspreeclampsia |
| spellingShingle | Shaole Shi Fangyuan Wu Shanshan Zhao Zilian Wang Yongqiang Fan Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study The Journal of Clinical Hypertension eclampsia Mendelian randomization plasma lipids preeclampsia |
| title | Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study |
| title_full | Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study |
| title_fullStr | Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study |
| title_full_unstemmed | Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study |
| title_short | Multidimensional Plasma Lipids Affect Preeclampsia/Eclampsia: A Mendelian Randomization Study |
| title_sort | multidimensional plasma lipids affect preeclampsia eclampsia a mendelian randomization study |
| topic | eclampsia Mendelian randomization plasma lipids preeclampsia |
| url | https://doi.org/10.1111/jch.14939 |
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