Microbiome compositional changes and clonal engraftment in a phase 3 trial of fecal microbiota, live-jslm for recurrent Clostridioides difficile infection

Microbiome compositional changes and clonal engraftment in a phase 3 trial of fecal microbiota, live-jslm for recurrent Clostridioides difficile infection

Live microbiota therapies have shown promise in many gastrointestinal diseases, including in the prevention of recurrent Clostridioides difficile infections (rCDI); however, frameworks for their pharmacokinetic and pharmacodynamic analysis are not fully established. Fecal microbiota, live-jslm (RBL)...

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Bibliographic Details
Main Authors: Josh Claypool, Gustav Lindved, Pernille Neve Myers, Tonya Ward, Henrik Bjørn Nielsen, Ken F. Blount
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Gut Microbes
Subjects:
CDI
Clostridioides difficile
dysbiosis
microbiota-based product
engraftment
pharmacokinetics
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2025.2520412
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