Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor

Reversing TGF-β1-induced fibrotic phenotype in human lung fibroblasts using a PROTAC tool derived from an indoline-based HDAC6 inhibitor

Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating interstitial lung disease characterized by limited therapeutic options, with only two FDA-approved palliative agents currently available. Given its poor prognosis and the high incidence of lung transplantation, there is a pressing...

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Main Authors: Ilaria Cursaro, Valerio Ciccone, Valeria Tudino, Chiara Papulino, Laura Scalvini, Sandra Donnini, Lucia Morbidelli, Luca Bini, Claudia Landi, Chiara Contri, Silvia Pasquini, Fabrizio Vincenzi, Katia Varani, Alessio Lodola, Marco Mor, Rosaria Benedetti, Lucia Altucci, Stefania Butini, Gabriele Carullo, Sandra Gemma, Giuseppe Campiani
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:European Journal of Medicinal Chemistry Reports
Subjects:
HDAC6
PROTACs
Pulmonary fibrosis
Targeted protein degradation
Epigenetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2772417425000329
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