Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death
Aging is a major risk factor for the development of cardiovascular diseases (CVD), leading to specific alterations in the heart and vasculature. Besides, the mechanisms and intracellular pathways of aging and the factors affecting it are still not completely clear. Age-related complications such as...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906725000326 |
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| author | Zohreh Zavvari Oskuye Keyvan Mehri Jamal Khalilpour Samira Nemati Leila Hosseini Soleyman Bafadam Naseh Abdollahzade Reza Badalzadeh |
| author_facet | Zohreh Zavvari Oskuye Keyvan Mehri Jamal Khalilpour Samira Nemati Leila Hosseini Soleyman Bafadam Naseh Abdollahzade Reza Badalzadeh |
| author_sort | Zohreh Zavvari Oskuye |
| collection | DOAJ |
| description | Aging is a major risk factor for the development of cardiovascular diseases (CVD), leading to specific alterations in the heart and vasculature. Besides, the mechanisms and intracellular pathways of aging and the factors affecting it are still not completely clear. Age-related complications such as oxidative stress, decreased autophagy, mitochondrial dysfunction, inflammatory responses, and cardiac dysfunction are associated with relative Klotho deficiency. Klotho, an anti-aging protein, with anti-oxidative and anti-inflammatory properties, has been shown to modulate calcium regulation and autophagy. It also protects against endothelial dysfunction by increasing nitric oxide production. Furthermore, emerging research has revealed that klotho significantly impacts vascular smooth muscle cells (VSMC) energetics and survival. This article has focused on recent advances in using Klotho in age-related CVD and summarizes the pre-clinical evidence supporting this approach. Based on the research, Klotho could provide more therapeutic options for ameliorating aging-related CVD. |
| format | Article |
| id | doaj-art-da7b05fbfd5b44c6abb45cdcaf8676ca |
| institution | DOAJ |
| issn | 2352-9067 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj-art-da7b05fbfd5b44c6abb45cdcaf8676ca2025-08-20T02:59:50ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672025-04-015710162910.1016/j.ijcha.2025.101629Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell deathZohreh Zavvari Oskuye0Keyvan Mehri1Jamal Khalilpour2Samira Nemati3Leila Hosseini4Soleyman Bafadam5Naseh Abdollahzade6Reza Badalzadeh7Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran; Corresponding author at: School of Medical Sciences, Khoy Faculty of Medical Sciences, Khoy, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IranStudent Research Committee, Semnan University of Medical Sciences, Semnan, IranResearch Center of Psychiatry and Behavioral Sciences, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, IranNeurophysiology Research Center, Urmia University of Medical Sciences, Urmia, IranMolecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Physiology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author at: Molecular Medicine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Aging is a major risk factor for the development of cardiovascular diseases (CVD), leading to specific alterations in the heart and vasculature. Besides, the mechanisms and intracellular pathways of aging and the factors affecting it are still not completely clear. Age-related complications such as oxidative stress, decreased autophagy, mitochondrial dysfunction, inflammatory responses, and cardiac dysfunction are associated with relative Klotho deficiency. Klotho, an anti-aging protein, with anti-oxidative and anti-inflammatory properties, has been shown to modulate calcium regulation and autophagy. It also protects against endothelial dysfunction by increasing nitric oxide production. Furthermore, emerging research has revealed that klotho significantly impacts vascular smooth muscle cells (VSMC) energetics and survival. This article has focused on recent advances in using Klotho in age-related CVD and summarizes the pre-clinical evidence supporting this approach. Based on the research, Klotho could provide more therapeutic options for ameliorating aging-related CVD.http://www.sciencedirect.com/science/article/pii/S2352906725000326KlothoAgingCardiovascularMitochondrial dysfunctionCell death |
| spellingShingle | Zohreh Zavvari Oskuye Keyvan Mehri Jamal Khalilpour Samira Nemati Leila Hosseini Soleyman Bafadam Naseh Abdollahzade Reza Badalzadeh Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death International Journal of Cardiology: Heart & Vasculature Klotho Aging Cardiovascular Mitochondrial dysfunction Cell death |
| title | Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death |
| title_full | Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death |
| title_fullStr | Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death |
| title_full_unstemmed | Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death |
| title_short | Klotho in age-related cardiovascular diseases: Insights into mitochondrial dysfunction and cell death |
| title_sort | klotho in age related cardiovascular diseases insights into mitochondrial dysfunction and cell death |
| topic | Klotho Aging Cardiovascular Mitochondrial dysfunction Cell death |
| url | http://www.sciencedirect.com/science/article/pii/S2352906725000326 |
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