Peripherally administered TNF inhibitor is not protective against α-synuclein-induced dopaminergic neuronal death in rats

Peripherally administered TNF inhibitor is not protective against α-synuclein-induced dopaminergic neuronal death in rats

The underlying cause of neuronal loss in Parkinson's disease (PD) remains unknown, but evidence implicates neuroinflammation in PD pathobiology. The pro-inflammatory cytokine soluble tumor necrosis factor (TNF) seems to play an important role and thus has been proposed as a therapeutic target f...

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Bibliographic Details
Main Authors: Josefine R. Christiansen, Sara A. Ferreira, David E. Szymkowski, Johan Jakobsson, Malú Gámez Tansey, Marina Romero-Ramos
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
Subjects:
TNF
XPro1595
Neurodegeneration
Microgliosis
rAAV
alpha-synuclein
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000191
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