Sarcopenia in Peritoneal Dialysis: Prevalence, Pathophysiology, and Management Strategies
Sarcopenia, defined as the loss of skeletal muscle mass, strength, and function, is a significant complication in patients with chronic kidney disease, particularly those undergoing peritoneal dialysis (PD). This review explores the prevalence, pathophysiology, diagnostic challenges, and management...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Kidney Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059525000251 |
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| author | Xiaohua Hu Bibo Wu Yang Yang Liming Zhang Cheng Xue |
| author_facet | Xiaohua Hu Bibo Wu Yang Yang Liming Zhang Cheng Xue |
| author_sort | Xiaohua Hu |
| collection | DOAJ |
| description | Sarcopenia, defined as the loss of skeletal muscle mass, strength, and function, is a significant complication in patients with chronic kidney disease, particularly those undergoing peritoneal dialysis (PD). This review explores the prevalence, pathophysiology, diagnostic challenges, and management strategies of sarcopenia in the PD population. The multifactorial etiology of sarcopenia in PD, including protein-energy wasting, chronic inflammation, insulin resistance, and hormonal imbalances, underscores the complexity of its management. The prevalence of sarcopenia in patients treated with PD is influenced by age, duration of dialysis, and comorbid conditions, presenting a considerable variation across studies due to differing diagnostic criteria. Diagnostic challenges arise from fluid overload and the PD process, affecting the accuracy of muscle mass measurements. Intervention strategies focusing on nutritional supplementation and physical exercise have shown promise; however, the need for PD-specific diagnostic criteria and treatment protocols remains. This review highlights the critical effect of sarcopenia on functional status and survival in patients treated with PD, emphasizing the importance of addressing this condition to improve patient outcomes. Future directions call for comprehensive, longitudinal studies to better understand sarcopenia’s progression in patients treated with PD and the development of tailored interventions. |
| format | Article |
| id | doaj-art-da74b05f068c411c8c6aedce65b82dd3 |
| institution | OA Journals |
| issn | 2590-0595 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj-art-da74b05f068c411c8c6aedce65b82dd32025-08-20T02:26:16ZengElsevierKidney Medicine2590-05952025-05-017510098910.1016/j.xkme.2025.100989Sarcopenia in Peritoneal Dialysis: Prevalence, Pathophysiology, and Management StrategiesXiaohua Hu0Bibo Wu1Yang Yang2Liming Zhang3Cheng Xue4Department of Nephrology, Zhabei Central Hospital of Jing’an District, Shanghai, ChinaDepartment of Nephrology, Zhabei Central Hospital of Jing’an District, Shanghai, ChinaDepartment of Nephrology, 981th Hospital of PLA, Chengde, Hebei province, ChinaDepartment of Nephrology, Zhabei Central Hospital of Jing’an District, Shanghai, China; Liming Zhang, MD, Department of Nephrology, Zhabei Central Hospital of Jing’an District, Shanghai, 200070, China.Department of Nephrology, Zhabei Central Hospital of Jing’an District, Shanghai, China; Department of Nephrology, Shanghai Changzheng Hospital, Second Affiliated Hospital of Naval Medical University (Second Military Medical University), Shanghai, China; Address for Correspondence: Cheng Xue, PhD, Department of Nephrology, Shanghai Changzheng Hospital, Second Military Medical University (Naval Medical University), Shanghai, 200003, China.Sarcopenia, defined as the loss of skeletal muscle mass, strength, and function, is a significant complication in patients with chronic kidney disease, particularly those undergoing peritoneal dialysis (PD). This review explores the prevalence, pathophysiology, diagnostic challenges, and management strategies of sarcopenia in the PD population. The multifactorial etiology of sarcopenia in PD, including protein-energy wasting, chronic inflammation, insulin resistance, and hormonal imbalances, underscores the complexity of its management. The prevalence of sarcopenia in patients treated with PD is influenced by age, duration of dialysis, and comorbid conditions, presenting a considerable variation across studies due to differing diagnostic criteria. Diagnostic challenges arise from fluid overload and the PD process, affecting the accuracy of muscle mass measurements. Intervention strategies focusing on nutritional supplementation and physical exercise have shown promise; however, the need for PD-specific diagnostic criteria and treatment protocols remains. This review highlights the critical effect of sarcopenia on functional status and survival in patients treated with PD, emphasizing the importance of addressing this condition to improve patient outcomes. Future directions call for comprehensive, longitudinal studies to better understand sarcopenia’s progression in patients treated with PD and the development of tailored interventions.http://www.sciencedirect.com/science/article/pii/S2590059525000251Sarcopeniaperitoneal dialysisprotein-energy wastingmuscle massdialysistreatment |
| spellingShingle | Xiaohua Hu Bibo Wu Yang Yang Liming Zhang Cheng Xue Sarcopenia in Peritoneal Dialysis: Prevalence, Pathophysiology, and Management Strategies Kidney Medicine Sarcopenia peritoneal dialysis protein-energy wasting muscle mass dialysis treatment |
| title | Sarcopenia in Peritoneal Dialysis: Prevalence, Pathophysiology, and Management Strategies |
| title_full | Sarcopenia in Peritoneal Dialysis: Prevalence, Pathophysiology, and Management Strategies |
| title_fullStr | Sarcopenia in Peritoneal Dialysis: Prevalence, Pathophysiology, and Management Strategies |
| title_full_unstemmed | Sarcopenia in Peritoneal Dialysis: Prevalence, Pathophysiology, and Management Strategies |
| title_short | Sarcopenia in Peritoneal Dialysis: Prevalence, Pathophysiology, and Management Strategies |
| title_sort | sarcopenia in peritoneal dialysis prevalence pathophysiology and management strategies |
| topic | Sarcopenia peritoneal dialysis protein-energy wasting muscle mass dialysis treatment |
| url | http://www.sciencedirect.com/science/article/pii/S2590059525000251 |
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