Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin
BackgroundExtracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type 1 N-terminal Propeptide (P1NP) as a formation marker. P1NP is associated with mor...
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1191055/full |
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| author | Thomas Andersen Thomas Andersen Thor Ueland Thor Ueland Thor Ueland Pål Aukrust Pål Aukrust Pål Aukrust Dennis W.T. Nilsen Dennis W.T. Nilsen Heidi Grundt Heidi Grundt Harry Staines Volker Pönitz Frederic Kontny Frederic Kontny |
| author_facet | Thomas Andersen Thomas Andersen Thor Ueland Thor Ueland Thor Ueland Pål Aukrust Pål Aukrust Pål Aukrust Dennis W.T. Nilsen Dennis W.T. Nilsen Heidi Grundt Heidi Grundt Harry Staines Volker Pönitz Frederic Kontny Frederic Kontny |
| author_sort | Thomas Andersen |
| collection | DOAJ |
| description | BackgroundExtracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type 1 N-terminal Propeptide (P1NP) as a formation marker. P1NP is associated with mortality in the general population, however, its role in myocardial infarction (MI) is still uncertain, and P1NP has not been investigated in acute chest pain. The objective of the current study was to assess the role of P1NP in undifferentiated acute chest pain of suspected coronary origin.Methods and results813 patients from the Risk in Acute Coronary Syndromes study were included. This was a single-center study investigating biomarkers in consecutively enrolled patients with acute chest pain of suspected coronary origin, with a follow-up for up to 7 years. Outcome measures were a composite endpoint of all-cause death, new MI or stroke, as well as its individual components at 1, 2, and 7 years, and cardiac death at 1 and 2 years. In multivariable Cox regression analysis, quartiles of P1NP were significantly associated with the composite endpoint at 1 year of follow-up with a hazard ratio for Q4 of 1.82 (95% CI, 1.12–2.98). There was no other significant association with outcomes at any time points.ConclusionP1NP was found to be an independent biomarker significantly associated with adverse clinical outcome at one year in patients admitted to hospital for acute chest pain of suspected coronary origin. This is the first report in the literature on the prognostic value of P1NP in this clinical setting.Clinicaltrials.ygov IdentifierNCT00521976. |
| format | Article |
| id | doaj-art-da722ff5ed9a4d04a696e5f84b6e3412 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-da722ff5ed9a4d04a696e5f84b6e34122025-08-20T03:30:35ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-09-011010.3389/fcvm.2023.11910551191055Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary originThomas Andersen0Thomas Andersen1Thor Ueland2Thor Ueland3Thor Ueland4Pål Aukrust5Pål Aukrust6Pål Aukrust7Dennis W.T. Nilsen8Dennis W.T. Nilsen9Heidi Grundt10Heidi Grundt11Harry Staines12Volker Pönitz13Frederic Kontny14Frederic Kontny15Department of Anesthesiology, Stavanger University Hospital, Stavanger, NorwayDepartment of Clinical Science (K2), University of Bergen, Bergen, NorwayResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, NorwayThrombosis Research Centre (TREC), Department of Clinical Medicine, UiT—The Arctic University of Norway, Tromsø, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwayResearch Institute of Internal Medicine, Oslo University Hospital Rikshospitalet, Oslo, NorwayInstitute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, NorwaySection of Clinical Immunology and Infectious Diseases, Oslo University Hospital Rikshospitalet, Oslo, NorwayDepartment of Cardiology, Stavanger University Hospital, Stavanger, NorwayDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Clinical Science, University of Bergen, Bergen, NorwayDepartment of Pulmonology, Stavanger University Hospital, Stavanger, Norway0Sigma Statistical Services, Balmullo, United KingdomDepartment of Cardiology, Stavanger University Hospital, Stavanger, NorwayDepartment of Cardiology, Stavanger University Hospital, Stavanger, Norway1Drammen Heart Centre, Drammen, NorwayBackgroundExtracellular matrix (ECM) is an integral player in the pathophysiology of a variety of cardiac diseases. Cardiac ECM is composed mainly of collagen, of which type 1 is the most abundant with procollagen type 1 N-terminal Propeptide (P1NP) as a formation marker. P1NP is associated with mortality in the general population, however, its role in myocardial infarction (MI) is still uncertain, and P1NP has not been investigated in acute chest pain. The objective of the current study was to assess the role of P1NP in undifferentiated acute chest pain of suspected coronary origin.Methods and results813 patients from the Risk in Acute Coronary Syndromes study were included. This was a single-center study investigating biomarkers in consecutively enrolled patients with acute chest pain of suspected coronary origin, with a follow-up for up to 7 years. Outcome measures were a composite endpoint of all-cause death, new MI or stroke, as well as its individual components at 1, 2, and 7 years, and cardiac death at 1 and 2 years. In multivariable Cox regression analysis, quartiles of P1NP were significantly associated with the composite endpoint at 1 year of follow-up with a hazard ratio for Q4 of 1.82 (95% CI, 1.12–2.98). There was no other significant association with outcomes at any time points.ConclusionP1NP was found to be an independent biomarker significantly associated with adverse clinical outcome at one year in patients admitted to hospital for acute chest pain of suspected coronary origin. This is the first report in the literature on the prognostic value of P1NP in this clinical setting.Clinicaltrials.ygov IdentifierNCT00521976.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1191055/fullbiomarkersacute coronary syndromesmortality/survivalrisk factorsextracellular matrixcollagen |
| spellingShingle | Thomas Andersen Thomas Andersen Thor Ueland Thor Ueland Thor Ueland Pål Aukrust Pål Aukrust Pål Aukrust Dennis W.T. Nilsen Dennis W.T. Nilsen Heidi Grundt Heidi Grundt Harry Staines Volker Pönitz Frederic Kontny Frederic Kontny Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin Frontiers in Cardiovascular Medicine biomarkers acute coronary syndromes mortality/survival risk factors extracellular matrix collagen |
| title | Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin |
| title_full | Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin |
| title_fullStr | Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin |
| title_full_unstemmed | Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin |
| title_short | Procollagen type 1 N-terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin |
| title_sort | procollagen type 1 n terminal propeptide is associated with adverse outcome in acute chest pain of suspected coronary origin |
| topic | biomarkers acute coronary syndromes mortality/survival risk factors extracellular matrix collagen |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1191055/full |
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